mcbain

No, us locals don't know them all either!

> Captain and first officer are reported to have died in the accident, two fire fighters on board of the truck received serious injuries, 13 passengers received injuries.

One caveat is that regular PET isn't so good in the brain - there is so much metabolic activity that everything glows. So I get an MRI Brain to go with my regular full body PET/CT (cancer 5 years ago with recurrence 18 months later, currently NED).

Ipi/nivo/relatlimab and then a peptide vaccine that they haven't written up yet.

Once they primed his system they excised as much as possible and kept the immuno going while doing a course of radiation.

Profs Long and Scolyer work with melanoma where chemo is rarely used these days.

I think Petter's (Mentour Pilot) delve into it is quite good - there's a lot of detail I hadn't known.

All of these incur costs. How hard a cap do you want?

Nivo is used a lot for melanoma, also commonly in combo with ipi (ipilimumab, yervoy). Pembro (keytruda) is the other common one.

Anyway, any of these can have adverse effects so patients are closely monitored.

For me, my thyroid didn't like nivo much but recovered. But we stopped after a couple of cycles of ipi+nivo because I was starting to develop colitis. And more importantly it wasn't slowing development of my melanomas.

https://docs.aws.amazon.com/AWSEC2/latest/WindowsGuide/win-a...

The hint is the -mab naming.

Some of the pulse sequences are rhythmic and I find the entire thing somewhat meditative, but there are many other places I'd rather be.

Then stop talking like you understand cancer treatment or clinical trials, because it is exactly how it works for thousands of people every year.

> Too bad

Pardon me? "Too bad" that I had recurrence of cancer and that immunotherapy was starting to cause colitis? Immunotherapy which turned out was never going to work because of the genetics of my cancer, the sequencing of which was completed thanks to one of the multiple clinical trials I'm on.

I'm sorry about your mother, but spreading your ignorance does not help other people.

No you don't need to have failed other treatments before being added to a clinical trial. Quite the opposite in many cases - they have entry criteria so that they can be sure any effects (good or bad) can be linked to the trial and not from something else.

No if you got colitis from immuno, chemo won't "reset" it, but strong doses of steroids might. (We discontinued my immuno before I got to that point.)

Chemo is effective for a few cancers but not for others. Immuno might be the most effective for those. Or chemo followed by immuno. Maybe it is CRT (chemoradio).

Or maybe there is no systemic treatment and all we can use is surgery and then maybe RT.

Nivo is generally well tolerated, ipi less so. I only got to my 2nd cycle of ipi/nivo before we discontinued it. (I'd already had more cycles of nivo on a trial.) It can have neurological effects and encephalitis in rare cases, so maybe that's what they are referring to. I wouldn't say "poison" though.

As it happens, Prof Long is my medonc. We don't sit around chatting about Richard though, she's a bit busy on clinic days!

The discussion about snowman hole issues and other problems is really alarming.