HNHacker News
TopNewBestAskShowJobs

mainedotpy

52 karma · joined July 3, 2021

submissionscomments
mainedotpy··on Goodbye, Ozempic
You sure thats Ozempic? Sounds like Trulicity based on the dose.
mainedotpy··on Goodbye, Ozempic
I personally take ozempic and have also prescribed it to ~150+ patients for diabetes. I've maybe had to stop it in ~8 patients for tolerability issues.

We unfortunately usually dont get to hear many chiming in to say that they tolerated it just fine. I do (2mg/week), down 45lbs.

Being heavy is really bad for you. Don't be so quick to write it off d/t the possibility of vomiting.

mainedotpy··on Ask HN: Is it legal for an employer to post as you on Slack?
Understand that emotions may be running high, but they said "Thanks". It was a little shady to post as you, but it did no harm.
mainedotpy··on Ask HN: Favorite Purchases of 2022?
This was from banana republic [0]

Has a strong Bruno color and vibe [1]

Refs: 0: https://bananarepublic.gap.com/browse/product.do?pid=5020670...

1: https://www.youtube.com/watch?v=YRpvIiz9G8A

mainedotpy··on Ask HN: Programs that saved you 100 hours? (2022 edition)
Espanso [0] - such a useful text expander with easy inclusion of shell commands and many other features. I love this thing so much as someone in the medical field that I made my first ever open source contribution to it.

0: https://espanso.org

mainedotpy··on Ask HN: Favorite Purchases of 2022?
A cashmere hoodie
mainedotpy··on JSON Hero: Enhanced JSON structure visualization
Tried to use this with large (650+mb) FDA drug label JSON [0] and it does not work, offers no error message etc. Bummer.

0: https://open.fda.gov/apis/drug/label/download/

mainedotpy··on Ask HN: How do you change your budget around a big raise?
Great recommendation overall. I love his stuff.

I’m not in the extreme thrift camp but we have no debt aside from mortgage and aren’t into conspicuous consumption. Our van is an 03.

mainedotpy··on Ask HN: What is your experience with SSRIs?
I'm a residency trained pharmacist and someone whose life was improved immensely by antidepressants from ages 19 - 37(bupropion x 10+ years, SSRI x 2 years, SNRI x 5 years). These drugs will change your affect (your mood) but not your intellect.

I am also currently not on medication x 2 months for the first time in about 18 years, so I have seen myself both on and off meds and I have a deep mechanistic understanding of these drugs.

I promise you that no drug that you can take can make any permanent changes to *edit* to your mind (there are rare cases unrelated to SSRI where side effects like tardive dyskinesia or pulmonary fibrosis can be irreversible). The SSRI have about a 4-6 week period of onset and offset where the extra serotonin floating around starts to cause fewer serotonin receptors to be expressed and subsequently enhances your brain's sensitivity to serotonin. It is for this reason that you do not see results overnight when starting a serotonergic drug.

Stopping the drug, a similar effect is seen. I had about a week of slight discomfort related to withdrawal symptoms, then 2-3 weeks of feeling a bit slower than normal, and now I feel just fine. Throughout this whole brain remodeling process both on and off meds, I never lost a step at work, which is to say that I maintained excellent performance as a midlevel practitioner and maintained several side hustles and even started a consulting business.

My honest interpersonal advice (not medical advice) is to give meds a try man. Your life has been severely affected by your mental state, and you could potentially see significant improvement....but even if you dont, you'll stop the drug and be no worse off than when you started.

mainedotpy··on I'll curate a reading list for you, based on the topic you'll give me. For FREE
Cool challenge for you. I’ll give it a shot.
mainedotpy··on Windows Subsystem for Linux GUI
This could very well be the case, but as someone who is just dipping a toe into programming, installing and using WSL2 knowing that I can fall back on GUI when I can't figure out bash is a feature for me.