721 karma · joined January 20, 2019
Mobile support was a concern of mine as well but I just took the easy way out and make a simple SPA in javascript and futzed with the CSS until it looked good on my phone (also mostly ChatGPT). One explicit design principle was that I will never support anyone but myself, which simplified things greatly. The SPA interacts with a little CRUD app that uses a sqlite database to store my cards and activity.
That said, it is actively harmful when discussing components of Chinese characters - it hallucinates so much it's essentially unusable. I stick to traditional resources for that. I'm also reading as many scientific papers as before, there's really no substitute for that yet, and I haven't found it very good at literature searches.
You didn't mention caffeine, but the half life of caffeine can be over 12 hours. Even if you limit yourself to two cups of coffee at 8 am, you'd still have as much caffeine in you as if you had one cup of coffee at 8pm. The rule of thumb about "no caffeine after noon" is just unreasonable, it really should be "almost no caffeine".
Every time I look at electric cars there's always some insane choice, e.g. the brake lights don't turn on when regenerative braking is active, even though your car is rapidly decelerating. The touch screens are also a safety concern - you can't change the music or skip ahead on a podcast without taking your eyes off the road for a meaningful amount of time. The fact that you're paying well over the median price for a new car makes it even less appealing.
FWIW I don't own a car and I'm not in a hurry to get one.
If this is just how it is, the "more than one hundred languages" claim is a bit suspect.
inciteful.xyz is also really great at finding the important papers for a subject. As you add more papers the recommendations get better.
Also, even if it did integrate, there would be no promoter, so the vaccine gene wouldn't get expressed. So the only danger I see would be if it integrated into something functional, but the virus was going to do that anyway. But this is so improbable to begin with I wouldn't worry about it.
Frankly just getting it to work at all is the real hurdle in this case.
See also this review: https://link.springer.com/article/10.1007/PL00006261
They essentially propose that RNA molecules would be ligated to a small number of amino acids and would then use them for catalysis, and from there evolved the ability to create proteins that are not covalently bound to RNA. So this bridges the RNA world with the RNA-peptide world, and from there it's much easier to conceive of how we arrived at modern biology.
There's a good reason to think that this was the path, since in all organisms today, tRNAs are ligated to single amino acids during translation.