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joshuamcginnis

1,239 karma · joined November 14, 2014

Biologist and software engineer.

Researching fungal natural products and the use of generative AI in biotech.

josh at everymanbio.com

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joshuamcginnis··on OpenAI Is a Bad Business
I have tried other options and you're right, many of them are better at specific things. But I don't have the time or desire to manage lots of tools when ChatGPT is generally good enough for most use-cases.
joshuamcginnis··on OpenAI Is a Bad Business
I've tried the alternatives and even running my own models locally. There is just no other solution I could find that comes close to the general utility of ChatGPT for a broad range of use-cases. I hope someone disrupts them, but until then, ChatGPT is to LLMs what Gmail is to email for me. I love to hate them.
joshuamcginnis··on John Wheeler saw the tear in reality
Simply pointing out that there are alternative possibility is not an argument against a creator. It's possible the creator is a pink unicorn, but it's not likely.
joshuamcginnis··on John Wheeler saw the tear in reality
Why don't you provide your own logic chain for why God doesn't exist and I'll read and respond to your arguments.
joshuamcginnis··on John Wheeler saw the tear in reality
One cannot just "assume there's an uncreated universe". There's no evidence for that. I'm not saying it's impossible, but if we're going to use it to make conclusions, there's has to be some logical or observable basis for it. My arguments are based on logic and observation. It would be impossible to find the truth if we just dream up any possible scenario without actually drawing conclusions from the evidence in front of us.
joshuamcginnis··on John Wheeler saw the tear in reality
Ah, great question. OK, if there is a "God" explanation for creation and its a logically sound argument, then how do we know who or what this God is? Many religions claim to know, but how we can differentiate them and use logic, reason, science, etc to find this one true God. Is that the question you're after?
joshuamcginnis··on John Wheeler saw the tear in reality
In layman terms, what are the current cohesive and logical arguments for existence having no beginning?
joshuamcginnis··on John Wheeler saw the tear in reality
No one is claiming to know what happened prior to the Big Bang. Whatever existed before time had to be infinite. If you read my logic carefully, I believe I make a perfectly reasonable case for 1. the universe existing (which I think most people would agree, we are living in an existence) and 2. that existence having a start (e.g. the universe is expanding, light gets redder the longer it travels, etc) 3. Anything that comes into existence has a cause.

I think when you combine the scientific evidence with the logic and continue down that line, you can make a good faith argument for an intelligent creator.

joshuamcginnis··on John Wheeler saw the tear in reality
Maybe the name is what you're hung up on? Whatever this simpler thing is would still need to be timeless, spaceless, immaterial, possess intentionality, and decision-making capabilities.
joshuamcginnis··on John Wheeler saw the tear in reality
The logical error in your question is in the "that's external to God". Going back to my first post, the "cause" must be eternal (since it was what started time in order for existence to begin). And because this eternal cause was not affected or constrained by physical space, it had to be all-encompassing. Because of this, there could be nothing external to the cause (God).
joshuamcginnis··on John Wheeler saw the tear in reality
I'm not claiming to know to an infinitesimal degree of certainty; I'm simply presenting the evidence and making my case. There are many truths that cannot be proven in the way you'd like. Prove to me that you won't commit a murder tomorrow. Prove to me that George Washington was a real person. Prove to me that you love your family.
joshuamcginnis··on John Wheeler saw the tear in reality
I accept the universe has a cause because of the logic I presented earlier. Humans have no reason to believe there is existence without cause (if you can find a single example of something being created without a cause, you would change the course of human history!)
joshuamcginnis··on John Wheeler saw the tear in reality
The logic posted was in answer to _what_ is the cause, not _if_ there is a cause. I already made the case for there being a cause in my original post. Nothing comes into existence without a cause. The cause being a singular timeless eternal entity requires fewer assumptions than the multi-modal explanation theory the other user suggested.
joshuamcginnis··on John Wheeler saw the tear in reality
Regarding P2, there is ample cosmological evidence in the form of scientific theories like the Big Bang that provide strong support for the universe having a finite beginning.

There is nothing that comes into existence without a cause. From your innermost creative thoughts to a spot of mold on bread, to a new leaf on a tree, to the seemingly random emergence of a rain storm - all have a beginning and all have a cause.

Have you experienced something different?

joshuamcginnis··on John Wheeler saw the tear in reality
It's possible there are multiple explanations, I give you that. No one can know for certain. The argument against it; however, is more logically coherent and parsimonious than the multiple theory. Happy to dig into why that is if you want to go deeper.
joshuamcginnis··on John Wheeler saw the tear in reality
Here is the argument for a singular cause vs a plurality of causes:

1. Occam's Razor favors explanations with the fewest entities.

2. A single cause requires fewer assumptions than multiple causes.

3. Therefore, a singular cause is more parsimonious than a plural cause.

4. A singular cause ensures consistent intentionality and unified purpose.

5. Multiple causes would necessitate coordination and could result in conflicting intentions.

6. Therefore, the cause of the universe must be singular.

joshuamcginnis··on John Wheeler saw the tear in reality
I'm more than willing to volley these ideas with you but I'm not following. I didn't once use the word "object" so I don't follow your refutation here. Could you elaborate? Are you saying that my conclusion collapses to a single "cause" (which I'm calling God and you're calling an object?)
joshuamcginnis··on John Wheeler saw the tear in reality
1. Everything that begins to exist has a cause.

2. The universe began to exist.

3. Therefore, the universe has a cause.

4. This cause is uncaused, timeless, spaceless, and immaterial.

5. To create the universe, this cause must possess intentionality and decision-making capabilities.

6. Therefore, the cause of the universe is a personal, immaterial being: God.

joshuamcginnis··on Did you lose your AirPods?
I've washed (and dried!) my AirPods twice. They're still alive and kicking. Pretty cool.
joshuamcginnis··on A multimodal dataset with one trillion tokens
You might be interested in reading up on DNA sequence llm models and tooling.
joshuamcginnis··on PostgreSQL and UUID as Primary Key
> This identifier is a 128-bit quantity that is generated by an algorithm chosen to make it very unlikely that the same identifier will be generated by anyone else in the known universe using the same algorithm. Therefore, for distributed systems, these identifiers provide a better uniqueness guarantee than sequence generators, which are only unique within a single database.

https://www.postgresql.org/docs/current/datatype-uuid.html

joshuamcginnis··on Python Modern Practices
I like miniconda for managing personal python projects.
joshuamcginnis··on Fungus breaks down ocean plastic
I've actually isolated and sequenced the subject fungus (Parengyodontium album) from terrestrial sources. If you'd like to check out the photos (and DNA), check out:

https://www.inaturalist.org/observations/147456216

https://www.inaturalist.org/observations/150149352

joshuamcginnis··on Show HN: Resume Builder in Python
I'm still waiting on the resume builder that uses an llm to transform CVs into relevant titles and descriptions for adjacent related target positions.
joshuamcginnis··on AlphaFold 3 predicts the structure and interactions of life's molecules
Accuracy can be assessed two main ways: computationally and experimentally. Computationally, they would compare the predicted structures and interactions with known data from databases like PDB (Protein Database). Experimentally, they can use tools like x-ray crystallography and NMR (nuclear magnetic resonance) to obtain the actual molecule structure and compare it to the predicted result. The outcomes of each approach would be fed back into the model for refining future predictions.

https://www.rcsb.org/

joshuamcginnis··on Giant batteries are transforming the way the U.S. uses electricity
There is a company[0] here in rural Virginia buying up huge swaths of land (100-500+ acres) and filling them up with solar panels. From an energy perspective, it's wonderful. On the other hand, it is quite literally changing the views of our precious Blue Ridge Mountains from hills and mountains with seas of green pasture to rows of solar panels as far as the eye can see.

0. https://energix-group.com/

joshuamcginnis··on No one buys books
I'm not sure I'd phrase it as a _joke_, but I see your point. I think a lot of people aren't even aware of how much of their thinking is done for them. We all hold assumptions (like your comment) that are subject to different kinds of biases or influence. If you can read something that provides a framework for helping analyze your own decision-making and introspectively discover how you arrived at your conclusions, then I think that can be helpful.
joshuamcginnis··on No one buys books
That's encouraging. It's definitely not fluff and original. The feedback would be valuable even if you don't end up liking it.
joshuamcginnis··on No one buys books
I'm currently writing a book about independent thinking and I have zero expectations that it will sell even a single copy. However, the net gain I will get from having completed the goal of writing the book is invaluable to me personally.
joshuamcginnis··on Ask HN: One-person companies—how do you manage it all and stay sane?
I'm frequently reminded of the adage: "You want to go fast? Go alone. Want to go far? Go with a team." The team could be people or as others have suggested, tools and processes that reduce your workload.
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