257 karma · joined October 15, 2012
[0] https://www.public.news/p/first-people-sickened-by-covid-19
I guess we won't really know when the file system breaks or corrupts data
retatrutide sequence: YAQGTFTSDYSILLDKKAQAAFIEYLLEGGPSSGAPPPS
modified sequence to reduce GI symptoms: YAQGTFTSDYSILLDKKAHAAFIEYLLEGGPSSGAPPPS
The difference is in spot 18, where it swaps the alanine with a histidine, which may reduce GI effects/nausea.
reference: https://doi.org/10.7554/elife.68719
Another improvement might be to add amylin/calcitonin receptor agonist to the sequence (similar to cagrilintide). (reference: https://www.nejm.org/doi/full/10.1056/NEJMoa2502081)
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1) PT-141 is a peptide that releases sex hormone into the blood and literally makes you horny, and its primary use is for premenopausal women that have low sex drive.
2) PNC-27 is a peptide that supposedly attaches to the cell membrane of tumor cells and performs cell lysis (death) of the tumor cell, and it's supposedly affects many different kinds of tumor cells: breast, pancreatic, lung, colon, ovarian, cervical, and leukemia
3) Epithalon is a peptide that is noted for extending telomers on chromosomes, leading to longevity benefits.
4) MOTS-c is it peptide that in animal studies is shown to boost physical endurance and mimic molecular changes associated with training/exercise.
It is legal to sell research only peptides that are not FDA approved, but as soon you talk about efficacy and human use, you also become a target for the FDA warning letters. [1] [2] [3].
Anyone selling these peptides who are indexed by search engines face increase scrutiny immediately, especially if you're going to try to sell the patented ones, because then you're a Target of not just the FDA but also Eli Lilly... peptides are big business but it's big risk if you do it wrong.... Eli Lily wants people spending $1,000 per month to use these peptides.
I think the trick about selling peptides to people is to probably do it word of mouth, no indexing by google, no ads, double gated website with invite only structure.
[0] https://www.npr.org/2026/08/13/g-s1-138594/eli-lilly-files-6...
[1] https://www.fda.gov/inspections-compliance-enforcement-and-c...
[2] https://www.fda.gov/inspections-compliance-enforcement-and-c...
[3] https://www.raps.org/resource/fda-warning-letters-target-mar...
The hiding of this data only brings distrust to their frontier models. I think most people want to understand how something comes to a conclusion they don't want have that part left out on purpose...
it's this kind of behavior that forces people move to to open source models in the end, it's the lack of trust. the frontier model providers treat the end user/customer as a threat or adversary. Fable 5 is notorious for this. a lot of the serious questions you ask the model they won't even respond to you because of the woke guardrails. it wasn't only a couple weeks ago that huggingface had to use glm 5.2 to get the right answers about their security incident because Fable 5 didn't want to answer it.