91 karma · joined July 20, 2019
“There is no problem that can’t be made worse with surgery” - a cautionary phrase to counter “a chance to cut is a chance to cure”
“Never be the first or the last to do something” - in regards to the countless new widgets, fads, techniques etc that are all the rage at the time
“50% of of our current understanding is wrong, but we don’t know which 50%”
“A smart man learns from his mistakes, a wise man learns from the mistakes of others”
https://www.cms.gov/Medicare/Quality-Initiatives-Patient-Ass...
Beware of unintended consequences though, hospitals are less inclined to permit riskier surgeries on unhealthy patients if they think the risk of readmissions is too high. Good luck getting your knee replacement if you are a 300lb diabetic smoker.
Some are subjective like pain (VAS or visual analog pain scale, “rate your pain 1-10”), ability to do daily activities, “would you have this procedure again?”, return to pre-injury activity level, etc.
Others are objective like range of motion, strength, bone healing noted on Xray or ct, tendon / ligament healing observed on mri, histiologic healing observed from follow up biopsy, rehospitilzation rates, revision surgery rates, infection rates, or mortality rates (the ultimate objective outcome measure).
There is hardly a shortage of outcome measures out there, and researchers propose new ones all the time, but they need to be validated as relevant and accurate by other studies before they are widely adopted.
Here is a pretty good basic science review article about articular cartilage:
The part of this article that I find most interesting was identifying a marker that can differentiate ankle cartilage vs the hip. This is certainly a phenomenon that we all observe clinically, hip and knee arthritis is vastly more common than ankle arthritis despite the weight bearing surface of the ankle being significantly smaller (meaning more force per square area). When we do encounter ankle arthritis, it is almost always the result of prior intra-articular fractures or instability from chronic ligamenous injuries, not the normal osteoarthritic age related degeneration we see in hips and knees.
Let’s find out what makes ankle articular cartilage so special and sprinkle it in our hips and knees.