fasa99

(1) "All things are poison, and nothing is without poison; the dosage alone makes it so a thing is not a poison."

(2) assume it isn't absorbed into the larger body. Still the tissue absorbing it got a YUUUUGEEE dose. Then presumably most of it is washed out minutes later. So under that assumption we worry about localized tissue damage ---- --- which, if we're talking about things like cancer patients here who commonly get zapped with X-rays and gamma rays and antimatter and such, is perhaps not out of the ordinary. If there's no systematic damage the main concern would be cancer. If the skin dies, it can be fixed. And heck, a lot of cancer treatments also cause cancer i.e. many children with blood cancers go onto later get other cancers due to the medicinal cure of their blood cancer side effect.

Just to go off these great works, there's a wonderful academic piece on the interaction between cosmology, quantum particles, and the higgs field here: https://www.youtube.com/watch?v=FYJ1dbyDcrI

you can pull a heart rate from color amplification, same basic idea as motion amplification.

surely there are simpler ways of course if you've dealt with most hoodish ruffians, as the names tells us, the people of the hood love to wear hoodies - which generally work quite well to hide from cameras, especially those above, if the hood sags forward and over the face somewhat or these: https://en.wikipedia.org/wiki/Groucho_glasses

or outside or alongside hoodies, these can be seen as socially acceptable (mostly) ; https://slate.com/human-interest/2020/07/mask-of-your-own-fa...

>This will destroy the near shore ecosystem, because desalination dumps brine that kills everything,

WRONG WRONG!!!

No, we used the brines to create even more batries which store our solar charge Now we have POWER at day and at NIGHT. 24/7. 247 we are producing the brines, but then that goes onto make more batries. Ain't no ecosystem destroyed here (though I'm sure people will try to perform a regression of muh bad event unto muh new technology because that is a timelessly vogue thing to do)

"oh these new-fangled kids what with their superscalar processors. 100 instructions in a cycle, phooey! Back in my day, it was dang gummed 100 cycles for each instruction, and gosh darnit we liked it! Now that was just for the add instruction, a division, well some say they never figured out how many cycles that was because it took too long. I had an onion in my belt which was the style at the time"

the proof they are good for your health is they taste bad

there are many interesting anatomic variants one interesting thing is the muscles that move our "grasp" - to cause our fingers to close or open. One muscle, with a "lead" per each finger. anatomic variant is sometimes these include the pinky, sometimes they dont. The pinky has its own set of muscles in either case. If you try moving your fingers you can see there's a bit more traction with the pinky isolation versus other fingers and thats why

The impact didn't destroy society or anything, it damaged the field. It made people think "wow that's interesting, tumors have unique microbiomes". the article says:

Meanwhile, research groups that, according to Salzberg, relied on the study’s data are dealing with the fallout, as are the journals that published the work. The publishers or journal editors of eight studies have begun reviewing the papers, according to spokespeople at Springer Nature, Frontiers, Wiley and the American Association for Cancer Research. The corresponding authors of these studies didn’t respond to requests for comment.

Looking at the analysis critique, yes, the original paper had an awful analysis. It smacks of a wet lab or clinical administrator who knows nothing about bioinformatics, having work done by say a grad student who themselves are not experienced in the field but clever enough to stitch together a nice sounding pipeline and write a Nature paper about it, and perhaps a bit cocky. This, I have seen before first hand. The long and short of it is, they used a big database of all bacteria genomes, and guess what, if a human grinds in a wet lab sequencing a bacteria genome, sometimes a bit of human DNA slips into the bacteria genome assembly, particularly if this was done some 50,000 times for 50,000 bacteria. So their analysis made no consideration to removing alignments to the human (or any other contaminant) genomes. So maybe their system says "aha! this bacteria is Staph Aureus!" but actually the Staph Aureus sequence has a fragment of human genome because the sequencing project therein had light contamination. It's absolutely self evident that if they were sequencing bacteria DNA off tumors, they should have controlled for human DNA contamination, given that the tumor the bacteria is sitting on, that tumor has a lot of human DNA.

I figure it's both. There are 10 gorillion cops and municipalities. Some likely have policies and staff that get along well with the public and just try to administrate traffic in a safe and fair way. Some treat it as a cash cow and care more about the revenue stream than increase or decrease in harm. It's one of those things where both sides of the argument can be true in specific cases, making it perfect "internet debate" fodder.

"harmful content" is such a joke word. if a piece of text or media could harm people the military would have weaponized it long ago. Even monty python made a satire of such a "harmful content" scenario: https://www.youtube.com/watch?v=Qklvh5Cp_Bs Big tech's hyperbole of the word is even more severe than Monty Pythons absurdist satire. Sadly it's not a joke.

Well I think the nature of internet forum stuff is you sometimes take extreme examples and/or dramatic metaphors to illustrate the point in a way that, one hopes, is easy to see, without actual intent in hyperbole. It's also common as we see here to refute the metaphor but ignore the underlying argument, perhaps some sort of argument fallacy.

Anyway, here's the problem with unrealized gains. If stock go brrrrr up 10-fold, wow! Huge unrealized gains! Get taxed on it. Unexpectedly, now the stock crashes, or it's found the company was doing something illegal, or the finances were fraudulent, or it was a ponzi scheme, etc, etc. Now stock is worth -zero- dollars overnight. Now I don't exactly what the logistics are going to be, but even if you hit those unrealized gains in tax year 2023, and the stock collapses in tax year 2024.. you had better get those gains that you were taxed on (but never got!), you had better get them back, plus interest.

cumberland is already quite bohemian. 20k for free, and some houses can be had for that amount, is quite appealing to the home-owning bohemian. the only trick of it - said bohemian probably would need a remote job. not much locally. so the obvious play is to make it a remote paradise and focus the remainder of the economy on supporting both the essentials and the entertainment / night life of said remote worker

If you're in cumberland proper, your main option is cable, which is fine, fast and stable. since the culture is blue collar, their lineman due a perfectionist tier type guys who pride themselves in their craft. they have a guy there who does fibre and is pretty chill but ironically he only runs line rurally (not in the main urban core of cumberland). they have a startup-ish grass roots wireless based internet which is cool but kind of hard to plug into.

They also have various speakeasies fully in the classic unlicensed since but for obvious reasons I won't say where. I would call it a "deregulated" region. Whereas in most of MD you have vehicle emissions and all that redtape, none of it in cumberland.

there are methheads about but police force and community are hand in hand and highly functional

if you're in cumberland proper all you could want is walkable, including an amtrak station that links you directly to DC and chicago, walking distance

there is an aspect of xenophobia but generally if you live there a while, well, if you're willing to live in cumberland that's good enough for most people to welcome you. it does have a small town vibe as far as saying hello to everyone on the sidewalk as such

the other point people who visit may miss about appalachian culture (it is appalachian culture very much so, not maryland culture) is everyone dresses like a methhead, even people who aren't methheads, so take appearences softly.

It happens. A major landmark, let's say leap forward in my career - I applied to a job at (to keep it anonymous) let's say a research center in a scientific field that is maybe top #1 or #2 depending on whom you ask in that area. Swiftly rejected. Randomly, maybe 6 months later, a very exasperated PI from the same institution contacted me directly. She'd fished through the HR system, nobody good was sent through, she'd found me, went in for an interview. It all played out beautifully. Great team, one of the best jobs I've ever had, lifelong mentor & supporter & vice versa.

I think the question is who is the guy calling out irrelevant resumes, and are they qualified for it.

I completely agree with this ratio view. Too much on ships and not enough on HR -> need to decommission the excess ships. To be fair, part of the whole thing is that by the nature of the beast, this requires they have eyes on the macroeconomic structure on the scale of years, which isn't easy. Because that relates to their funding and how desperate people are for work. And ships and ship orders I'm sure take a few years to push through. All that being said, it would have been wise for them to have some hedges in place for such scenarios, and to consider non-traditional employment structures such as "sail from home" type work where employees zoom into the engine room

Your counterpoint presents citations from the year 2019 and circa 2012. OP there posted that they were now cheesing the numbers "for years" - seems to me "for years" might cover the range 2020 (COVID) - 2024, but not your citations. Anything that says under the post-covid administration they aren't cheesing the job numbers?

This article: https://recruitonomics.com/revisions-to-the-job-numbers-may-... Posits that indeed during recessions, most revisions are negative, and the reverse is true for economic booms.

So if we think maybe there's some kind of recession in the 2020-2024 time range it might be expected to see a series of downward revisions.

The more tender point is whether these ongoing downward revisions are simply the nature of the beast, or if someone is pressing their thumb and cheesing the numbers a bit to give the impression of no-recession. This is a tender point because some of the unemployment metrics are sus i.e. "people who have been looking for a job for 1-9 weeks, but not more, and it's a full moon on a Tuesday". The more that diverges from (100% - <Definitely employed %>), the more that definition of unemployed is cheesing it. But if the numbers are getting tuned up over here, it's natural to suspect the same party is tuning up numbers over there too.

It's very much patentable and thus represents an IP asset that can be traded, contracted, exchanged, etc, similar to a "technology invention". UCLA likely owns it or a part of it, so can trade it freely. This is quite very very early for a drug, so there's huge risk it will fail in human trails, so that high risk lowers the value significantly versus a phase III passed drug. There's a kazillion drugs like this, XYZ-123 type format, most of which failed or never reached Phase I, Phase II, phase III, phase IV, or phase kappa trials

Guys, guys. It's not about exercise. Cancer makes lactate independent of exercise. Exercise, in lack of oxygen, also makes lactate.

Here's the thing with cancer (1) sometimes it actually does lack oxygen, because it grows faster than blood vessels, so may prefer lactate creation, known as "fermentation" (yes, like beer which ferments sugar to alcohol, but humans ferment sugar into lactate). So the whole body may be bedridden, not exercising, but a little part of it is not getting oxygen. (2) EVEN IF there is oxygen available to the cancer cell, they have been shown to, EVEN THOUGH there is oxygen there, they still proceed through fermentation and produce lactate. And it's not well known WHY cancer cells do this. This paper suggests that it's a chemo resistance mechanism. Other thoughts have been that it simply pushes through more physical carbon atoms which help make more cancer faster.... this concept of "why does the cancer ferment even though oxygen is readily available" is known as "The Warburg Hypothesis"

Because with oxygen 30x more ATP is produced. Why would cancer seek the vastly more inefficient energy production pathway, the insinct is that cancer would be hyperefficient at being canerous.

Dunning-Kruger energy here...

What do they call it with packets, "quality of service"? FIFO.

It's a good plan but you have to make sure fairness is ensured. It's the same feeling as, if I go get a burger & fries, the guy behind me orders identically, burger and fries, and somehow gets served first. The instinct is to say, "what the heck, why does HE get fast service than me in a straightforwardly unfair manner?!?"

So you'd need the empty bus and full bus to hit the same spot at the same time, fill the empty bus as the full one unloads. But which bus leaves first? If the former empty bus leaves first, you're being unfair QoS to the people who are seated on the full bus (which, to their perspective, at their prior stop, was the first-in-order-on bus so therefore should be the first-in-order-off bus. On the other hand, if the full bus leaves first, why did you make incoming passengers board the empty one? They should have boarded the full one to get to their destination faster.

The solution, which we see in practice, is to have the empty bus wait 5 or 10 minutes and let the full one get ahead. If we are seeing rounded fairness to all parties as the priority.

You are 100% right but it's no reason to pick on web in particular! When you hit a site, you may have a virtual HTML environment running a JIT virtual machine from a server that's running a virtual python environment on a virtual python environment on a virtual machine on a virtual machine, and all that runs on a virtual x86 processor which in reality is a series of microcode processors. Yes, yes, it would be so much simpler to have your web go straight to the source, microcode, and yes, things would be simple and fast... .. but ... but ABSTRACTION!!!! LETS ABSTRACT EVERYTHING EVER AS MANY TIMES AS POSSIBLE WITH AS MANY ABSTRACTION LAYERS AS POSSIBLE IT GENERALIZES TO THE GENERAL CASE ABSTRACTION GENERALIZES ALL CASES WOOOOWWWW THE COMPUTER SCIENCE OF IT ALL

That is the state of things.

Exactly. I will make explain more how PS4 emulator can be achieve. First, you can make the whole universe. You need a universe for PS4 to live in. Then, you make do PS4 emulator. Now you have achieve.

It's hard to say what the motivation for the estrogen is but it's a case study in pharma-bro-ing type hobbies which is fine. Life extension nootropics and such. It could be a menopausal woman juicing up. It could also be a biological male who identifies as a female, which was big tech's engineering solution as far as how to get more women in tech (turns out, innovative solution, it's easier to retrofit male programmers as females than it is to convince your average woman to sit alone in a cubicle all day fighting against a pedantic and buggy compudah) - don't announce that at google, however, or you'll be punted out next day and end up needing to settle it for a few million.

google didn't so much kill a king as it maimed 6 billion peasants

What puts me off about the argument is along the lines of "and because of such and such, now numerically less guns exist in public, and that's -a good thing-"

For me this smacks of California style government i.e. "we've made gas and energy so expensive that people use less energy, and environmentally that's -a good thing-" or "we've made permit regulations so bad nobody is able to build anything anymore and environmentally that's -a good thing-"

The crux of these things is that if you presume that these are basic rights: not having property confiscating, building a house without too much red tape, free market energy economy - then we have arrived at -a good thing- via -an unethical thing- and thus it's a good outcome through an unethical means, or "fruit from the poison tree" as ethics states.

From a legal perspective, these are trying to avoid a completely hypothetical scenario of Peter's hypothetical gun hypothetically shooting Paul, or Peter's hypothetical +20% pollution hurting the life of Paul, and George got jammed up by the law and hates it, but the lawmaker who is worried solely about Paul is quite pleased with himself about having saved Paul from the hypothetical which may or may not have actually happened.

>Does reddit thought-police subreddits, or do they thought police curate the site as a whole? Yes. 2 million updoots say this is the rightthink, reddit user, you want to think right don't you?

for sure.

for me this hits hard. I've literally made most of my whole career off one famous song called "Do you like Pina Coladas" (but actually it's called "Escape"). A good number of people know the tune but few could tell you who made it :(

I say this from personal experience in medicine - many of them come here under highly auspicious circumstances e.g. "I claimed asylum because XYZ, and XYZ just so happened to be at the time I was 8.9 months pregnant, which circumstantially will just so happen to make my child a US citizen and thus qualify me for welfare, WIC, and free food, vis a vis my citizen-child, of which I definitely won't have 10 more of once I'm here"

The issue isn't asylum or american dream, both are fine. The issue is 10-20 million people milking the housing, welfare, and medical systems -really hard-. In the clinics, some days, 100% of patients were Spanish only speaking i.e. recently arrived here or not-so-recently arrived here and never bothered to learn english. Which is a cost to the public coffers. Not the baseline medical cost, a Spanish interpreter is legally required according to another medical related law, an additional cost.

That's to say, let's eradicate all financial governmental "free money" type motivations +/- "free citizenship to anchor babies" motivations as to why a person would come here. People wistfully point to Ellis Island as the spirit of America, in that spirit, let these immigrants make their way on their two feet with their two hands, without support, as those of Ellis Island, as those before, did.

The big pain of it is many of these people come from collapsed socialist countries, but maintain some degree of socialist ideals, so they try very hard to extract socialist benefits in the US. It's like guy, why did you think you country collapsed? Oh sorry, you don't speak English, el guy-o, el-why-o el country-o el collapso?

It may also have nothing to do with friendships with the accused offender whatsoever. Maybe they also hate the accused offender.

One thing big orgs do a LOT LOT LOT of is cover-ups. I would imagine (gut estimate) 1% or less of such saucy dramatic events ever float out into the public due to limited media coverage and cover ups. It's not about covering whatever accused who is accused of doing this, no, it's about protecting the fine name and reputation of the firm.

So they aren't saying necessarily "we don't care" in a typical case, more like "we care.. buuuut we care way more about our own org, so we're hushing this all up like it never happened and it will never see the light of day".

This is particularly true of very big or very prestigious orgs, your McKinseys, your Goldman, Your Harvard, your Stanford, your federal government, and so on

The "E" (environment) portion may sometimes be useful. Specifically, a more efficient or recycling focused approach, if common-sense in nature, may boost internal efficiency. Recycling (item X) means you don't need to buy a new one, means saved costs, means environment karma upvotes.

But it's not karma upvotes that causes company to do this, nor is it that our companies are governed by rabid hyperleft liberals. It's that one particular ibank, Blackrock, is governed by a rabid hyperleft liberal, thus anyone who wants his money, will also hit the "D" and "I" initiatives. And by "his money" I mean "all of our money" which is a massive collection of investments funds that blackrock manages and uses as a kudgel for these social initiatives. That's all to say, hiring XX people of YY skin color may result in ZZ concrete additional dollars of funding or stock price, which under certain circumstances may be a profitable transaction.