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erhk

534 karma · joined October 4, 2019

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erhk··on Why Google's Plan to Cut Remote Worker Pay Is a Bad Idea
Advising someone do their own research is a cheap way to circumvent providing any sources.
erhk··on Why Google's Plan to Cut Remote Worker Pay Is a Bad Idea
Thats quite idealistic
erhk··on Your app is not compliant with Google Play Policies: A story from hell
Dont worry, google is working hard to make sure that even employees are unable to do anything of that sort. Gather the world's information and make it uniformally unsupported.
erhk··on Oregon reports first 3 cases of drug-resistant 'superbug' fungus Candida auris
1150 us cases already. These are just the first oregon ones...
erhk··on No one is certain what Roman bronze dodecahedrons were used for (2018)
Has anyone tried polishing one and putting it on a necklace? Could be a fashion piece, how does it look when the sun hits it?
erhk··on No one is certain what Roman bronze dodecahedrons were used for (2018)
Why keep a utility object alongside wealth objects?
erhk··on No one is certain what Roman bronze dodecahedrons were used for (2018)
How would you use this as a sex toy
erhk··on Children born in the pandemic have significantly reduced cognitive performance [pdf]
Another outsize impact of overreaching quarantine restrictions. Why do we let politicians rather than epidemologists make these decisions?
erhk··on Tell HN: AWS appears to be down again
Any public communication is handled by people not machines. No one wants to make an automated status page because theres a shit ton of real noise that users dont need to hear about, nd theres a lot of outages that automation won't accurately catch
erhk··on Tell HN: AWS appears to be down again
I hope that their infra is not that unstable
erhk··on Omicron variant more resistant to vaccine but causes less severe Covid: study
Birth control kills more women annually then any covid vaccine. If you engaged in non-procreative sex in the past year you've done something which has a greater risk for human life and health.
erhk··on Omicron variant more resistant to vaccine but causes less severe Covid: study
Probably because you paid them to let you.
erhk··on AWS us-east-1 outage
It has customer relationship implications. I guarantee you it is updated by a support agent.
erhk··on The Effects of Major Retailers Raising Their Minimum Wages
If you follow housing policy you might find wealthy benefactors
erhk··on Ask HN: Why doesn't anyone create a search engine comparable to 2005 Google?
Trusted curators is a dangerous dependency
erhk··on The slowest SR-71 Blackbird fly-by
Lucky 10,000
erhk··on Heavily mutated coronavirus variant puts scientists on alert
Mutations which improve transmission and longetivity will, in general, become more prevalent. Proliferation begets proliferation. You cannot transmit a strain if you are at home in bed from its severity.

Help me understand how a virus can replicate without being detected but can also increase its lethality.

We already have an asymptomatic and infectious incubation period. If that kept stretching longer then you are delaying the lytic cycle even longer? Or does propogation and ultimately viral load also happen as a slower burn? Eventually you will have damaged too many cells.

erhk··on Heavily mutated coronavirus variant puts scientists on alert
Alpha falls into the variant of concern classification, and this is contrasting delta with non-VOCs unless I misunderstand.
erhk··on Heavily mutated coronavirus variant puts scientists on alert
What is a less than optimal response? Partial binding?
erhk··on Heavily mutated coronavirus variant puts scientists on alert
Has any vaccine in known history been truly 100% effective? "Immunity" was never the goal to my understanding.
erhk··on Heavily mutated coronavirus variant puts scientists on alert
What does region mean in this context? A region of the body?

Antigen binding?

Your statement on future infections by a distinct antigen than you were immunized for is objectively true. A vaccine is not a panacea for all viruses.

If I prepare my home for a flood then I shouldn't expect an earthquake to be stopped.

If we are making the case that a surface protein is too targetted then I would point towards the seasonality of the flu.

erhk··on Heavily mutated coronavirus variant puts scientists on alert
Please get vaccinated.
erhk··on Heavily mutated coronavirus variant puts scientists on alert
I have seen no evidence to support this yet but I do not mind being proved wrong.
erhk··on Heavily mutated coronavirus variant puts scientists on alert
Alpha was more lethal than delta from the sequencing reports posted by my State in the U.S.

.4% lethal compared to .3% lethal when I last checked.

So thats one goalpost. Another litmus test is that if delta was more lethal it would have been a very popular media talking point. Fear is unfortunately a successful motivator for clicks.

erhk··on Heavily mutated coronavirus variant puts scientists on alert
>In fact the better the virus gets at infecting our cells and evading immunity, the more likely it is to also spread to dangerous / lethal levels before our immune systems are able to stop it.

Can I ask for some related literature on this topic? This contradicts my understanding.

erhk··on Heavily mutated coronavirus variant puts scientists on alert
Thats quite an obtuse response that I doubt most health experts would agree with let alone most countries.
erhk··on Heavily mutated coronavirus variant puts scientists on alert
Are there studies which back this? Are we sure that reducing virus in solution will improve immune response? Has any study been conducted on the efficacy of zinc supplements when sick with covid?
erhk··on Heavily mutated coronavirus variant puts scientists on alert
Natural immunity isnt viable for the people likely to perish if they are infected.

Yes you should get vaccinated even if you tested positive because false positive tests can occur.

There is no verifiable record of anyone having been sick with covid in the same way that there is for vaccination.

"Immune system robustness" is not something quantifiable or comparable in human populations to my knowledge. We can identify immune system weaknesses or compromise but I do not know of a metric to rank individuals relative to each other.

erhk··on Heavily mutated coronavirus variant puts scientists on alert
Nasty mutations here referring to solely increased binding to ace2 receptor and increased transmissibility, but not lethality afaict.
erhk··on Heavily mutated coronavirus variant puts scientists on alert
If you trigger a memory response why would it matter if it was recalling a different similar protein? Wouldnt your immune system also remember and respond to a real pathogen, suggesting that the orginal vaccine was sufficient? In what world do you identify a pathogen but the fail to respond to it? Its not as if your body responds significantly differently to distinct illnesses.

Perhaps my understanding here is too cursory but this claim is pretty extraordinary for what I know.

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