63 karma · joined January 9, 2014
http://www.nejm.org/doi/full/10.1056/NEJMoa1307491
doi://10.1056/NEJMoa1307491
Background
Autism involves early brain overgrowth and dysfunction, which is most strongly evident in the prefrontal cortex. As assessed on pathological analysis, an excess of neurons in the prefrontal cortex among children with autism signals a disturbance in prenatal development and may be concomitant with abnormal cell type and laminar development. Methods
To systematically examine neocortical architecture during the early years after the onset of autism, we used RNA in situ hybridization with a panel of layer- and cell-type–specific molecular markers to phenotype cortical microstructure. We assayed markers for neurons and glia, along with genes that have been implicated in the risk of autism, in prefrontal, temporal, and occipital neocortical tissue from postmortem samples obtained from children with autism and unaffected children between the ages of 2 and 15 years. Results
We observed focal patches of abnormal laminar cytoarchitecture and cortical disorganization of neurons, but not glia, in prefrontal and temporal cortical tissue from 10 of 11 children with autism and from 1 of 11 unaffected children. We observed heterogeneity between cases with respect to cell types that were most abnormal in the patches and the layers that were most affected by the pathological features. No cortical layer was uniformly spared, with the clearest signs of abnormal expression in layers 4 and 5. Three-dimensional reconstruction of layer markers confirmed the focal geometry and size of patches. Conclusions
In this small, explorative study, we found focal disruption of cortical laminar architecture in the cortexes of a majority of young children with autism. Our data support a probable dysregulation of layer formation and layer-specific neuronal differentiation at prenatal developmental stages. (Funded by the Simons Foundation and others.)
This is speculative, but I think Telegram actually has enough momentum at the moment to overtake WhatsApp as the main instant messaging service in the Netherlands--if they are able to adequately handle the massive amount of new registrations. The general public definitely seems to be uncomfortable privacy-wise with the acquisition of WhatsApp by Facebook. So much for privacy being dead.
https://twitter.com/search?q=telegram%20lang%3Anl&src=typd&f... Telegram is definitely a trending topic on Twitter in the Netherlands.
As of now, there are no known fatal flaws or weaknesses in the Bitcoin protocol itself. The network is secure and as long as you manage to secure your private keys, Bitcoin is extremely safe.
The legality of this is interesting. I suppose it takes a peculiar legal structure to operate a botnet lawfully.
Paywalled article: https://www.sciencedirect.com/science/article/pii/S002251931...
Abstract:
Host manipulation by sexually transmitted parasites which increases host mating rate and thus parasite transmission rate has long been viewed as a plausible parasite adaptation. However, empirical evidence for it is rare. Here, using an adaptive dynamics approach to evolution, we explore conditions under which such disease-induced mating enhancement is (or is not) likely to occur. We find that increased mating success is less likely to evolve if the host reproduction rate, or the baseline disease transmission rate, is reduced, and the parasite affects just one sex, compared to when it affects both. We also find that it is less likely to evolve if the virulence-transmission trade-off curve is stronger, since we assume that enhanced disease transmission can only be achieved at the cost of increased virulence and as this trade-off is concave. In addition, we demonstrate that if disease-induced mating enhancement is equally acting in both sexes the mating system has no effect on evolutionary outcomes. On the contrary, if disease-induced mating enhancement is acting in just one sex, the potential for its evolution increases with the degree of polygyny in the host population. To study the examined phenomenon in greater detail we encourage further empirical research on this apparently less explored impact of sexually transmitted parasites on host fitness.
Paywalled article: https://www.sciencedirect.com/science/article/pii/S030646031...
Abstract:
The aim of the present study is the investigation of the potential role of negative relating to others, perceived loneliness, sadness, and anxiety, as mediators of the association between early parental bonding and adult Internet Addiction (IA). The factorial structure of the Internet Addiction Test (IAT) and the prevalence rates of it in a Greek sample will also be investigated. A total of 774 participants were recruited from a Technological Education Institute (mean age = 20.2, SD = 2.8) and from high school technical schools (mean age = 19.9, SD = 7.4). The IAT was used to measure the degree of problematic Internet use behaviors; the Parental Bonding Instrument was used to assess one's recalled parenting experiences during the first 16 years of life; the shortened Person's Relating to Others Questionnaire was used to assess one's negative (i.e. maladaptive) relating to others (NRO). Both exploratory and confirmatory factor analyses confirmed the three-factor structure of the IAT. Only 1.0% of the sample was severely addicted to the Internet. The mediated effects of only the NRO and sadness were confirmed. Negative relating to others was found to fully mediate the effect of both the father's optimal parenting and affectionless control on IA, whereas sadness was found to fully mediate the effect of the mother's optimal parenting on IA. Overall, the results suggest that parenting style has an indirect impact on IA, through the mediating role of negative relating to others or sadness in later life. Both family-based and individual-based prevention and intervention efforts may reduce the incidence of IA.
Edit: Never mind, you already answered it in another comment.
I would not recommend you to do a mass censorship scan from your own IP. It's a given that one or more of the top 100,000 sites triggers some kind of flag, apart from the fact that such activity itself may mark you as a person of interest.
Another thing to consider is that the government can likely link your YCombinator account to you because there are few YCombinator users in Iran, and from that subset, only a small number (maybe 1) matches your posting timestamps. I'm of course assuming that they keep such traffic logs. Syria's surveillance system did/does.
Paywalled article: http://psycnet.apa.org/doi/10.1037/a0035546
Abstract:
The placebo effect is any outcome that is not attributed to a specific treatment but rather to an individual's mindset (Benson & Friedman, 1996). This phenomenon can extend beyond its typical use in pharmaceutical drugs to involve aspects of everyday life, such as the effect of sleep on cognitive functioning. In 2 studies examining whether perceived sleep quality affects cognitive functioning, 164 participants reported their previous night's sleep quality. They were then randomly assigned to 1 of 2 sleep quality conditions or 2 control conditions. Those in the "above average" sleep quality condition were informed that they had spent 28.7% of their total sleep time in REM, whereas those in the "below average" sleep quality condition were informed that they had only spent 16.2% of their time in REM sleep. Assigned sleep quality but not self-reported sleep quality significantly predicted participants' scores on the Paced Auditory Serial Addition Test and Controlled Oral Word Association Task. Assigned sleep quality did not predict participants' scores on the Digit Span task, as expected, nor did it predict scores on the Symbol Digit Modalities Test, which was unexpected. The control conditions showed that the findings were not due to demand characteristics from the experimental protocol. These findings supported the hypothesis that mindset can influence cognitive states in both positive and negative directions, suggesting a means of controlling one's health and cognition. (PsycINFO Database Record (c) 2014 APA, all rights reserved).
Abstract:
Increased activity of the sympathetic nervous system is thought to play a role in the development and progression of cardiovascular disease. Recent work has shown that physical inactivity versus activity alters neuronal structure in brain regions associated with cardiovascular regulation. Our physiological studies suggest that neurons in the rostral ventrolateral medulla (RVLM) are more responsive to excitation in sedentary versus physically active animals. We hypothesized that enhanced functional responses in the RVLM may be due, in part, to changes in the structure of RVLM neurons that control sympathetic activity. We used retrograde tracing and immunohistochemistry for tyrosine hydroxylase (TH) to identify bulbospinal catecholaminergic (C1) neurons in sedentary and active rats after chronic voluntary wheel-running exercise. We then digitally reconstructed their cell bodies and dendrites at different rostrocaudal levels. The dendritic arbors of spinally projecting TH neurons from sedentary rats were more branched than those of physically active rats (P < 0.05). In sedentary rats, dendritic branching was greater in more rostral versus more caudal bulbospinal C1 neurons, whereas, in physically active rats, dendritic branching was consistent throughout the RVLM. In contrast, cell body size and the number of primary dendrites did not differ between active and inactive animals. We suggest that these structural changes provide an anatomical underpinning for the functional differences observed in our in vivo studies. These inactivity-related structural and functional changes may enhance the overall sensitivity of RVLM neurons to excitatory stimuli and contribute to an increased risk of cardiovascular disease in sedentary individuals. J. Comp. Neurol. 522:499–513, 2014. © 2013 Wiley Periodicals, Inc.
This is much more intrusive and not comparable to a company ad in my local newspaper or a magazine to which I'm subscribed.