chromatin

This is a fantastic ad for GLM-5.3

I started to correct you that the limit was surely 0.05%, but then I saw you snuck a per-mille sign in, instead of a percent sign. Nicely done

An alternative hypothesis is that it's low because our most talented kids know they can make a ton more in finance and tech

I can think of at least one person who failed out of my medical school class

> From a more practical angle, I don’t know how you could possibly find more doctors by lowering their earning potential.

You certainly could if you were willing to accept people who are terrible at being a physician.

The notion that you can just throw more warm bodies at the problem is ludicrous

> Their salaries need to be lower, training needs to be cheaper and faster, and we need a lot more of them.

The quality of the average physician is already so low I am not sure what you are hoping to accomplish with lower salaries and faster training.

Doctoring isn't a matter of more warm bodies

Yes I am aware but the comment explicitly compared it to JetKVM, not the mini which is not yet available anyway

It's not though.

JetKVM typically $100-120 ArkKVM $99-115

Extremely relevant:

Ramp Router: https://news.ycombinator.com/item?id=48987253

Looks like it will be a paid offering? Seems strange coming from a Fintech, unless they're looking to pivot.

A 1 gbe local network should have < 1 msec latency per hop so theoretical upper bound is substantially higher than 30 tps (again assuming instantaneous compute) => thus network latency should not be the limiting factor in reality, no?

I would very much like to see a Lightning-Network based 402 standard succeed!

The UX is awful - I bailed out at 25/100 JUST IN LEVEL ONE (BASICS)

Might I suggest adaptive difficulty? After getting 10, 15, 20 correct in a row it should scale up the difficulty immediately, rather than waiting for 100 in the basic level 1...

We noticed this years ago when looking at -- IIRC -- ikaros antibodies. They were clearly faked. Lacking any sort of platform to gain attention we moved on to Abcam and our lab just sort of maintained a mental map of who not to purchase ANYTHING immuno- from.

> Do you need to predict when AP-MS is so cheap?

Yes because a core reason fro this technology is evaluation of de-novo designs (small peptide binders; scFvs; sdAbs)

If you had read the article, you'd have seen that UUIDv4 with Rowid was slightly slower than UUIDv7

Is this substantially different, cognitively or skills-wise, than moving into management and directing a team to write code, but no longer writing code oneself?

"Practice is policy"

I disagree and think GP poster is right on the money.

There are many ways in which inflation numbers are cooked; just one of them is the hedonic adjustment [1].

Others include an un-representative basket of goods.

The basket of goods is adjusted every 2 years, but not necessarily in a way that mirrors the way real households adapt their spending patterns to increased prices.

Owner equivalent rent (LOL) massively lags behind home prices.

Honestly, when 10s or hundreds of millions of people's perception does not match *Official Government Numbers*, then it's reason to suspect that the official numbers are a poor metric.

[1] https://www.bls.gov/cpi/quality-adjustment/

I love that you are doing this test. However, as it purports to be a test of "English-to-SQL", your hardest question (Q9) seems ungrammatical:

> Show order lines, revenue, units sold, revenue per unit (total revenue ÷ total units sold), average list price per product in the subcategory, gross profit, and margin percentage for each product subcategory.

In particular, the clause "in the subcategory, gross profit, and margin percentage for each product subcategory" is ambiguous, and I wonder if more models would pass if the English were reformulated to be correct.

(it's also notable that Claude Opus 4.6 and Sonnet 4.6 both "missed" this one)

Incredible; I'll let my patients* on Home HD know about this.

*not a nephrologist but have several pts on home hd

> Delve was founded in 2023 by Karun Kaushik and Selin Kocalar, both Forbes 30 Under 30 members and MIT dropouts who met as freshmen.

Forbes 30 under 30 remains undefeated

No, not at all. My unqualified internet diagnosis is that you may have high anxiety.

When I was a young(er) postdoc and had to overhaul my bicycle -- my main transportation to work-- this site was invaluable. Forever grateful to Sheldon.

> According to linguists, elongated variations such as "heyyy" could be construed as flirtatious, "hellaw" might suggest you're from the southern US,

I am from the Southern US and I am definitely not familiar with this phonetic form. Could be what a BBC writer _imagines_ a Southerner sounds like

I found Croatian significantly easier than Czech, perhaps because of centuries (millenia?) of trans-Adriatic Italian influence?

Time is your most precious commodity.

Conduit [1] has retention policies [2] for media and attachments!

[1] https://conduit.rs/ and https://gitlab.com/famedly/conduit [2] https://gitlab.com/famedly/conduit/-/blob/next/docs/configur...

> Intentionally not bothering to go into why, but above average intelligence.

Speaking as a geneticist, it's a shame that this is forbidden knowledge

I've found the same. I've moved from a homebrew tinkerer's delight home network with pfSense running in a VM, Supermicro FreeBSD ZFS fileserver, hodgepodge of cameras etc. to a top-to-bottom Unifi Stack.

My time is worth a lot more now, my family appreciates very much that it "Just Works" (tm), and -- most importantly -- the cognitive load for me is a fraction of before.