checoivan

Ray Cronise also gave a talk at ted med about how the cold can increase fat loss.

http://www.youtube.com/watch?v=UrQ_ldCwKUQ

Ironic that Kodak started the technological change that made it obsolete. They invented the digital camera sensor.

Seems like Kodak tried investing the right area but executed very poorly. Cameras are a great business, just look at how well Nikon or Canon are doing. Cinema digital camera market is just rising by RED and recently Canon. Why a company that started and was leading camera sensor technology, OLED displays, with tons of know how of imaging technology ended up turning into selling cheap point and shoots is beyond me.

You are right. Apps are the new golden handcuffs for users of a current platform and are a new challenge to overcome for both android and windows phone.

Still there's millions of new users who are just about to get a new smartphone coming from candy bar phones, and when shopping they just go mostly look up for the iphone. I stood up at an ATT store some times watching how people shopped phones. The color squares of Windows Phone and huge screens of android phones attract people initially, but as soon as they start comparing they flock to the iPhone.

Amazingly, I just got back from a vacation in Mexico where smartphones are just becoming popular, and went to the local vendors out of curiosity. The push for IOS/android is impressive, there are ads on the street, movies, everywhere. You can get an iPhone with no downpayment and 600 pesos(45 usd) a month.

The lateness is not that important since phone contracts are up in about 2 years and at the time, people shop for new phones and usually aim for the coolest one as their new phone. Phone markets renew every couple of years but clearly the iphone keeps beating the value(how many iphone's generation 1 do you see on the street?). The iphone was even late to the game but that didn't stop it from taking away the coolness and market of the motorola Razr which everybody wanted and had back then.

Another factor is the Windows phone, Android and iPhone have about the same initial and per month cost. Roughly the same price but All 3 give very different values back in terms of apps,feature,ease of use. Coping with the downsides or nuances is also a 2 year commitment so unless an option is clearly way ,way better, people will stick with an iPhone or go back.

With pcs it's a different ballpark. A macbook feels nicer than a generic Acer notebook, but one costs $1,500 and the other $499. The phones are all around $199 and plans are about 70 bucks a month. Even if the phone is "free" the per month payment is the same.

Also the iPhone sets a standard of experience which still is unmatched. If I drove a mercedez, then switched to an Acura and didn't like it as much, it doesn't mean either is bad. Acura is awesome, but I might miss the feeling,driving, status,smell, etc and hold the Acura up the Mercedez standards. Windows phone is stuck in an unconfortable situation where it doesn't give way greater value to an iphone user but doesn't cost way less either to make it into other emerging markets and grab marketshare from somewhere else.

Some windows live properties backends use SqlServer as well and have thousands of SQL instances running, so it does scale.

http://windowsteamblog.com/windows_live/b/windowslive/archiv...

From Mexico myself as well.

The whole ordeal is by far more complicated than in the US, except for visas.

Starting is already hard enough by itself, so adding on top a thick layer of hoops to jump and bypass in Mexico isn't the best of things. The market is different, the talent pool is vastly different than sillicon valley.

There's a big focus in custom enterprise applications and consulting among CS workers and grads, very little product focus. There's a mindset gap where the majority of people believe starting, and doing something without getting squashed by El Goog or government is impossible. Convincing people that things "can be done" is an uphill battle.

Incubators are more of the generalist type.I applied and spent some time on my university incubator ("Tec") and found that the focus was in manufacturing, trading, and finance business. There was very little knowledge of tech startups. Accounting/Hr/taxes are pretty draconian as well.

Interesting. There's a similar research about a content centric based internet coming out of Xerox PARC.

http://gigaom.com/cloud/how-parc-wants-to-reinvent-the-inter...

Most are overlooking the change in thinking with these servers.

Think of servers with ARM processors in the pipeline which will come with 64+ cores, available for cellphones. The biggest problem in a datacenter is not space or processing power, it's energy consumption and heat dissipation. Walking into a datacenter gives you the feeling that the place looks empty with plenty space to fit 6x more servers. Today this can't be done because there's no capacity for more air conditioning to cool more servers in the building.

Also, the way of processing has changed in the last years, for example with map reduce, which makes having many cores way more useful than a single server with a massive 5 ghz core. Actually today, many servers are IO bound, not CPU bound. There's exceeding cpu capacity.

Think of having a server, with 64 ARM cores and and array of SSD's. This won't heat up as much as mechanical disks or today's cpus, with very small IO constraints due to SSDs speeds and far more parallel processing power.

This is awesome. I remember playing metroid at a friend's house who had a NES, wondering "Why do all rooms look similar?!". We spent hours drawing maps by hand so we wouldn't get lost through levels.

The map is super clever. The whole game map is 1Kb of memory (MetroidTilePage.txt:line 4658). A 2d array and each byte has the ID of a room sprite.

So that's why all rooms were the same :)

I don't know the details, but whatever sequencing queries Monsanto is running against cloudant, would be nice to replicate and open source to universities and researchers.

+1 on that.

Yes, you can be a PM without knowing code, but it's hard to be an excellent one.

A technical PM maybe doesn't code on a daily basis anymore, but one who understands technical challenges is highly valuable. A good PM who knows the chops can easily debug things when a customer calls, design good features and know whether it'll be easy or hard to implement,set more realistic goals,or call out BS from developers who says some easy task will take 4 weeks or something is impossible to implement.

This is huge. Recollected pluripotent cells can only be reproduced and divided a very limited number of times with the techniques we know so far (it used to be ~2x). A big problem was that only a very small amount of stem cells usable for treatment can be collected from ,say, like a placenta.

Agreed. "The-Dip" is a great read on this topic. His basic premise is great in the sense that it's not about quitting or sticking into something for sake of stubbornness.

It's all about knowing what It'll take to quit before hand, see if it's worth starting, and improve the odds of making it past the dip.

I was starting something, when my dad got sick. Visa/money/cofounder is a problem most of us have,but just one an extre hump to get through. After I had to fly back home and take care of things. It was really hard for several months to focus on work, when the top idea on my head was family, and pulling stunts with hospitals/insurers.

I love seeing this. C++ is one of those things taken for granted because it's been there for so long, in a sort of love it or hate it way. Good to see all those C++0x changes are coming into shape and being implemented.

As much as I love newer technologies like python or JS, we still need things like C++ to get the cooler stuff running on metal. It's great to see improvements on this areas.

I don't think HP is throwing the towel, just not putting all eggs in a single basket. They know now how big a challenge is to turn it around on the tablet market. Cloud's the thing now so they're also getting into it.

I asked myself the same question once. Having worked a bit on this before on msft I learned that builds, just like other dev tools, need constant improvement as complexity increases. Faster builds, customization and allowing scripting, parallel building, etc... It's one of those things taken for granted because it's always been there, like the F5(compile), but It's a tool which can be improved just like any other.

An H1b can be transferred so you can switch companies with it.

I agree you could argue that. But rather than crunching numbers, I think his point was to illustrate the state of some cancer treatments today. How despite of everything and all advances in medicine,we still need to make HUGE improvements in cancer.

For example, pancreatic cancer. Prognosis is 20% 1 year survival and five-year rate is 4%. The best approved treatment so far is Gemzar, which was introduced in the early 80's. It's improve rate over other chemos was that it works in 23% of the patients, and improves the median survival to 5.65 months compared to 4.41 months with 5-flu chemo.

Over 20 years and some of the best we got is +1.2 months and for only 23% of the patients. That's what he's pushing for and I support,improving this rates.

In the end It's not about crunching numbers and making one disease or other look better tackled. It's about having hope for all this people and know something can be done, instead of staring at such a grim prognosis.

Similar story here. Mom died of the same disease.

I did join a stem cell related company from their beginnings. It was cool to see it grow thinking I was doing good, until I realized at least in my case it was more about making the owners money rather than finding cures for these kind of diseases.

Quitting the day job and switching to biomed maybe could help, but I believe instead there's a need to start something more radical rather than being +1 cog.

This is incredibly good news. So many researchers have been looking for a way to alter the inmmune system to target cancer, and it's surprising (but also makes sense) that the solution seems to be around HIV. It's this kind of out of the box thinking that pushes forward.

And this: "this small trial involving just three patients was lucky to go ahead at all. The study was rejected by pharamceutical companies and the National Cancer Institute.".

There's a very good talk on TEDMed from David Agus, about proteomics and cancer research. He bubbles up a similar concern about limitations of clinical trials.

http://www.ted.com/talks/david_agus_a_new_strategy_in_the_wa...

Do something you love.

It's not about marketing, Apple is brilliant in making a feature easy and discoverable.

On spot comment. Cloud file storage and auto replication, file and document automatic sync,Web versions of office. Msft has that. You can even extend sync through API's.

Features are there, but seems like nobody knows about it, discoverability is lacking.

There's a money incentive at work for each patent submission.

Every time I stare at that patent submission form I can't help but to imagine somebody doing a cool thing which does something similar, getting squashed by a lawyer.

I've a couple of those forms which I filled, but never submitted.

Well, nothing prevents nintendo from using wii controllers and games on the new console, and possibly scaling them up to make them look better. Just lookup Wii HD on youtube to see the games running on 1080p on an emulator.

Also sounds like now you will be able to buy DS and Gameboy games from the marketplace as well.

I'd get one just to play Donkey Kong Country,Zelda,and Metroid in Xbox like graphics.

Though the leak says no 3D now, looks like a classic Nintendo move where in 2 years an upgraded 3D screen controller will be out at ~80 bucks each.

Visual Studio side by side with emacs.

Most of the time on Windows Server 2k8R2 64 bits. Dual Xeon w/12gb of ram.

There's a theory about this. If one starts by learning object orientation first, it becomes second nature and easier to write well structured code afterwards(thinking of making smaller component, good structures etc) instead of vice versa, starting with procedural code and learning objects afterwards.

That's why most colleges start with Java and learn basics and object orientation, then move to C to learn memory management,pointers etc, and then Lisp and data structures to expand one's mind.

Though some courses start now with python which I find extremely cool. If I were to start again I'd like python since you can hack fully functional programs more quickly, and think about lists and data structures first instead of way later on. It also helps to rule out faster if the person is meant for programming or not.

Well... We all know what happed to admirals Ozzel and Mottie when they said "no repro" and "woops, missed that" in the daily scrum with Darth Vader.

Kudos on this. Great to see a good place to find this type of data, specially since other sources like Nature are very expensive.