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carbocation

14,964 karma · joined September 7, 2009

Cardiology & human genetics.

Previously founded MyChances.net (acquired by Parchment in 2011).

Email: james@{my HN username}.com

https://carbocation.com

topcolor #f6f6ef

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carbocation··on Aaron Swartz was prosecuted for scraping, while Meta does it without consequence
It originated in a comment on a blog: https://crookedtimber.org/2018/03/21/liberals-against-progre...
carbocation··on NIH is ending a key grant for budding clinical researchers
The public overwhelmingly supports NIH-funded research. https://www.aacr.org/about-the-aacr/newsroom/news-releases/n...
carbocation··on Irish datacenters now guzzle 23% of the country's electricity
That is essentially how it works in the US as well thanks to public service loan forgiveness for physicians.
carbocation··on Apple Neural Engine: Architecture, Programming, and Performance
This scans very much as AI-written.
carbocation··on Running local models on an M4 with 24GB memory
Was the choice of such a small model driven by a desire for high tok/sec? I ask because an m4 pro 48gb machine can run larger models (if model intelligence is the thing that would make it more useful).
carbocation··on AlphaEvolve: Gemini-powered coding agent scaling impact across fields
Last month, Steve Yegge suggested that they are not: https://xcancel.com/Steve_Yegge/status/2043747998740689171
carbocation··on Claude Opus 4.7
Neat, thank you for explaining!
carbocation··on Claude Opus 4.7
Is there a page where I could read more? What's unintuitive at a glance is that Opus 4.7 has a lower success rate than Sonnet 4.6 (90% vs 100%) while having a higher Avg Percentile (87.2% vs 70.9%).
carbocation··on ChatGPT Pro now starts at $100/month
The $20 Plus plan still exists, and does not give access to the pro model.

The $200 Pro plan still exists, and does give access to the pro model.

What is new is a $100 Pro plan that does give access to the pro model, with lower usage limits than the $200 Pro plan.

carbocation··on Gemma 4 on iPhone
It would be very helpful if the chat logs could (optionally) be retained.
carbocation··on Iran launched unsuccessful attack on UK's Diego Garcia
The article kind of downplays the most interesting elements. Not an expert, but to my limited understanding:

* I think this is the longest-range use of a ballistic missile in anger, possibly ever?

* This seems to reveal previously-unknown range of Iranian ballistic missiles and, if true, could touch basically all of Europe?

carbocation··on Waymo Safety Impact
I think the average is ballpark 1 per 100 million miles, so my guess is that someday they might show this, but they probably want to wait til they have more miles driven.
carbocation··on Urea prices
Haber-Bosch process, for the curious.
carbocation··on Ggml.ai joins Hugging Face to ensure the long-term progress of Local AI
Because many of us think simonw has discerning taste on this topic and like to read what he has to say about it, so we upvote his comments.
carbocation··on Gemini 3.1 Pro
I agree with this; it feels like the most likely tool to drop its high-level comments in code comments.
carbocation··on Voxtral Transcribe 2
This model was able to transcribe Bad Bunny lyrics over the sound of the background music, played casually from my speakers. Impressive, to me.
carbocation··on Two days of oatmeal reduce cholesterol level
300 grams of oatmeal a day, basically nothing else, and your LDL only goes down 10%.
carbocation··on Dead Internet Theory
Em-dashes are easy to type on a macos laptop for what it's worth: option-shift-minus.
carbocation··on Erdos 281 solved with ChatGPT 5.2 Pro
The erdosproblems thread itself contains comments from Terence Tao: https://www.erdosproblems.com/forum/thread/281
carbocation··on Show HN: 22 GB of Hacker News in SQLite
That repo is throwing up a 404 for me.

Question - did you consider tradeoffs between duckdb (or other columnar stores) and SQLite?

carbocation··on United 777-200 fleet faces an uncertain future after Dulles engine failure
The article explicitly says that the aircraft is safe. I don't think this is particularly clickbait-y.
carbocation··on Covid-19 mRNA Vaccination and 4-Year All-Cause Mortality
> The public database of reported post-vaccination health issues is often misused to sow misinformation.

https://publichealth.jhu.edu/2022/what-vaers-is-and-isnt

carbocation··on Covid-19 mRNA Vaccination and 4-Year All-Cause Mortality
VAERS cannot be used to establish causality; it cannot correctly be used in the way in which they are purporting to use it[1].

1 = https://www.kff.org/quick-take/fda-memo-linking-covid-vaccin...

carbocation··on WebR – R in the Browser
If the URL is public, it would be neat to see if you want to share it.
carbocation··on Building more with GPT-5.1-Codex-Max
It would be great to have access to this model via the chat interface, even if it was gated behind the "other models" dropdown or something.
carbocation··on Caffeinated coffee consumption or abstinence to reduce atrial fibrillation
To add more information, the intervention was guidance about caffeine intake. From the Methods:

> If allocated to caffeinated coffee consumption, patients were encouraged to drink at least 1 cup of caffeinated coffee (or at least 1 espresso shot) and other caffeine-containing products every day as per their usual lifestyle. It was recommended that patients in the coffee consumption group not intentionally increase or decrease consumption of coffee or other caffeine-containing products.

> If allocated to the abstinence group, patients were encouraged to completely abstain from coffee, including decaffeinated coffee, and other caffeine containing products.

carbocation··on Waymo Was on a Roll in San Francisco. Then One of Its Cars Killed a Cat
Waymo was on a roll in San Francisco. It still is, but it used to be, too. (With apologies to Mitch.) This is utter sensationalism. Fortunately, the state's regulations have liberated the good people of SF from being able to shoot ourselves in our own foot on this particular issue.
carbocation··on Ticker: Don't die of heart disease
The claim on an individual level is not objectionable to me. The question is that if we extrapolate it out to the population and actually take this action for everyone, do we make people better off? This is what clinical trials (or at least large observational studies) try to achieve. Right now, it is not clear.
carbocation··on Ticker: Don't die of heart disease

    Key Takeaway: Get a CT or CTA scan, and if you can afford it go for the CTA with Cleerly.
There is a reason that we don't recommend getting imaging for everyone, and that reason is uncertainty about the benefit vs the risks (cost, incidentalomas, radiation, etc, all generally minor). Most guidance recommends calcium scoring for people with intermediate risk who prefer to avoid taking statins. This is not a normative statement that is meant to last the test of time: it may well be the case that these tests are valuable for a broader population, but the data haven't really caught up to this viewpoint yet.
carbocation··on My Impressions of the MacBook Pro M4
One thing that wasn't mentioned is the max sustained screen brightness for SDR, which is higher on the M4 Pro (1000 nits) compared to the M4 Air or M1 Pro (500 nits).
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