I'm an American (Texan) who has been living in Germany for the past 6 years. I would suggest to consider the culture and lifestyle more than the work, as those will play a much larger role in your happiness and satisfaction. It sounds cliché, but money doesn't necessarily buy happiness.
I enjoy living in German/European cities significantly more than I did living in big cities in Texas (I can't speak for the East Coast). I value the culture of being able to walk or bike pretty much anywhere in the city in a reasonable amount of time. I value feeling safe even in the "bad" neighborhoods here in Germany. I've never once come across a situation where I was worried about my safety here, I can't say the same for the US. I value a society that isn't so extreme (wealth inequality, political ideology, etc.).
As for what I miss about the US, it's mostly the food (TexMex, BBQ) and nature (so much more to see and do, but you need a car). There's also the work culture which is a bit different, particularly in terms of startups and innovation; Germany definitely lags behind in this aspect. Some things are more convenient in the US as well, such as stores being open later and on Sundays.
Germany isn't perfect, but I think it's better than the US in a lot of quality of life aspects.
Before moving, I would recommend going to visit the city and see if it's something that might fit you. Try to talk to locals and explain your situation, I'm sure there would be people happy to show you around and give you some good insights from a less touristy perspective.
Of course, all of this is hard to weigh if your wife will be living there for certain, as long-distance relationships can be tough.