amts

If I am visiting Twitter once in 3 months, I will still need to pay 1$ per month? if true, then even if I'd like to use Twitter more often, I will quit. What an idiot.

The reason for asking this question was that maybe it's possible to deduce something about such CEO. As he is not even using a calendar or mobile app to schedule his tasks upfront of at least a week, they want an assistant to remind him of everything. It seems for me that if they want someone to totally manage his time, it by default may not be 100% effective if the person didn't make a conscious action to put something on a calendar.

A company with this name is a pharmaceutical company, it seems so unprofessional to me

Yes the first name only

Main actually offers 3/4 full time in the beginning and a hybrid model, so I may be this long commuting only ~3 days a week. Just hate to choose between apparently equally acceptable offers.

I may be hired as the bureau coordinator/SEO's assistant and on my CV I mentioned that I am just learning all this stuff from multiple online and offline resources. Formally I have completed 3 introductory courses on Python on Coursera and 2 certification courses on FreeCodeCamp in Python for Data Analysis and Scientific Computation (actually wrote and understood code), and watched (without practice) dozens of them on Django/Flask to get familiar which I would re-watch with more attention and practice by now. Because anyway I will need Python/C++ programming for my biophysics projects.

By "keywords" I mean just the names of the tools/frameworks/concepts.

I posted a few links about WP being hacked below. It may be that's all I've seen on HN.

I just searched on HN for the most recent 2-3 years and found this:

[1] https://news.ycombinator.com/item?id=31584788 Researcher goes public with WordPress CSP bypass hack

[2] https://news.ycombinator.com/item?id=32561198 Hacked WordPress – over 17,000 spam links injected post compromise

[3] https://news.ycombinator.com/item?id=5702570 Tell HN: Bots are Constantly trying to hack your Wordpress Sites

There are more dating 5 and more years ago, but I didn't link them here. It seems I saw at least twice as more similar news for WP in recent years, but maybe these links were in HN server cache or something and with no comments so are not shown in search.

Do you include ChatGPT in the calculation of the slope?

Or here's a follow-up question: can Django/Flask provide the same functionality/user experience as Wordpress?

You can connect a ~3-10V battery to yourself, which may increase an electrostatic field and deflect the incoming signal.

It may be a typical informational website for a small agency with up to 3-4 tabs, presenting their services, a blog, some contact form. It may not need much animation or interactivity in the beginning. But optimization for mobile may be useful. I've watched a dozen of tutorials on Django/Flask on Pluralsight/FreeCodeCamp building some simple registration sites, even a basic e-shop. For my former Wordpress site I have several plugins, including SEO optimization. But you mean to not install even the Wordpress recommended plugins?

It is recursively ingrained into the current spacetime data structure itself [1]. So no wonder.

[1] https://www.youtube.com/watch?v=RCSSgxV9qNw Why Is 1/137 One of the Greatest Unsolved Problems In Physics?

This was mentioned for the proof of principle only. But nothing spectacular will happen, it may be necesssary to adjust statistical analysis to account for the variable number of parameters and to make appropriate comparisons if necessary.

Cocaine is anesthetic in one context and stimulant in another. Meth can be sedative in specific contexts (according to dr. Andrew Weil). The classification above may be partially useful, but obviously not effective.

Datura being anticholinergic degrades the effect of acetylcholine, which is one of the components of (regular) attention. So no wonder it seems scary. But would you have the same experience after, for example, 10 days of continuous mindfulness/focusing meditation? Or after 30 days?

Though toxicity seems the main difference, comment above is talking about experience and not molecular mechanisms of action.

In a similar vein, if someone would ask a distinguished professor of neuroscience to provide a full description of the exact brain molecular state that "generates" an exact salvia experience (including any communicative content), s/he would fail.

>>Datura is a deliriant.

Such definition includes very little context. You should try more functional, mindful set&setting based approaches.

I updated conda with this: $ conda update -n base -c defaults conda

Or to minimize the number of packages updated during conda update use

    $ conda install conda=23.7.3

Or conda update -all

But I thought using the openai API key for jupyter_ai will be free as with ChatGPT 3.5.

Electricity/Magnetism isn't understood well enough by modern human monkeys yet. The default representation of electrons as particles gets so ridiculous in AC context. Like, suppose you'd like to transfer N buckets of energy in the form of apples to a monkey zoo. You'd just straight move them from their departure point to their destination point in the zoo. Now if electrons are supposedly just tiny particles of the same type and you'd like to transfer some energy from point A to point B via an AC transmission line, why would you need to toss them to and fro between these points at 50/60Hz frequency in order to deliver to point B instead of just straight passing from A to B? This is ridiculous.

And here's another one https://en.wikipedia.org/wiki/Amplituhedron

The main risk I heard about is tissues with rapid cell turnover, but some startups are working on it.

It may have already been solved with _partial_ epigenetic reprogramming with Yamanaka or related factors, where _partial_ means not pushing cells all the way back to embryonic/cancerous state and maintaining their differentiation.

Strangely enough he is taking NR (nicotineamid riboside) rather than NMN, probably as there was recent evidence (including on HN) that NMN can evoke cancer (in those who are prone to cancer or already have it).

>> There are some formulations that purport to have higher bioavailability on a gram-for-gram basis according to trials, but their price is often high enough that it’s cheaper to take more of a generic CoQ10 than to buy an expensive formulation.

Isn't bioavailability ensured mainly by a liposomic form? Sinclair mentioned in podcasts that he is taking for example 1 gram of resveratrol with a pinch of jogurt (=fat) to increase bioavailability. If you take a powder form capsule with a pinch of olive oil, shouldn't it increase its bioavailability? (to cheaply emulate a liposomic form)

>> This in turn has been linked to under-methylation, and mitochondria play a role in a lot of processes involving methylation.

Do you mean epigenetic methylation? As the cellular reprogramming techniques for example strive to reverse the current pattern of epigenetic methylation.

The neuroscience-based literal cures for bullshit are the following:

1) temporal reduction of serotoninergic transmission in the right hemisphere of the human brain; 2) caloric vestibular stimulation (of the left ear);

all of which are supposed to induce some critical thought. Caloric vestibular stimulation is basically pouring cold water into the left ear, which is supposed to induce a specific pattern of activity in the right hemisphere, which have been shown to reverse pattern non-recognition.

Why can't psychiatrists prescribe those treatments for politicians etc? Because psychiatry itself is a bullshit medicine.

It's basically as Python keyword 'as' implies: spacetime and whatever it contains including gravitational bending being a data structure (one of many), which obviously is not just another object in spacetime, but spacetime itself. There's one cognitive neuroscientist, a few physicists and mathematicians who're developing this.

Spacetime as a data structure

Ion channels are also a hyper-conserved mechanism as every cell needs to maintain a resting potential, and there are tons of ion channel modulating drugs approved and used messing with the with billion years old hyper-conserved mechanism.

I heard about NAD+ on Dave Asprey podcast, that with age the NAD cleavage system cleaving NAD excess is also degraded and a Nuchido company makes this supplement with additives targeting NAD cleavage system restore as well.

I heard about this anti-oxidant hype, so the original psilocybin study now seems a bit incomplete.

There are a ~dozen of studies on dasatinib (anti-cancer drug) + quercetin (senolytic) for curing osteoarthritis in humans, improving heart tissue etc, with dasatinib used as a senolytic. Navitoclax (anti-cancer drug) also used as senolytic in some studies.

In this context it seems that adverse effects from senolytics may be more pronounced in cancer-prone, in younger age or if taking them continuously (not like 5 days per month or so letting some senescent cells to emerge). Yet Sinclair's new venture TallyHealth, for example, are selling a 5 in one capsule, containing apart from other stuff 500 mg quercetin and 100 mg fisetin (senolytics) with an expectation of daily intake. And his 80y old dad is taking senolytics daily with still no cancer.

I'm not trolling, this probably is some effect of the psychoactives' field itself and thinking about it.

I am researching the topic about how signalling molecules find their intra- and extracellular targets amongst multiple potential "distractions" along their way. What you describe as 'lock-and-key' or 'induced-fit' relationship is established only at the direct contact of a ligand with the receptor. While the ligand in vivo if not injected locally first needs to move fast through vast distances (relative to its size) until it reaches the receptor. It seems that it is just accepted for granted, as if the ligand "knew" where the receptor is.

Your link and explanation are very informative, it seems like this intramolecular hydrogen bond completes a "virtual" third heterocycle in the whole molecule. While senolytic quercetin, for example, also has 3 benzene rings.

There's a doctor in my contacts who weighs heavily on heterocycles due to the delocalized electron they contain.