I have to wonder how long the drug industry knew about this, but just brushed it under the rug like they do with all of their drugs, just to get them approved.
When there's money to be made, dangerous side effects don't matter to them.
868 karma · joined January 3, 2018
When there's money to be made, dangerous side effects don't matter to them.
You don't want to stop a fever ~ just keep it within the safe zone where it's healing, but not dangerous.
Drug companies hate it when a cash-cow drug is threatened in any way. Anything that threatens those profits is a potential target in one way or another. Researchers studying these drugs know just how much power and influence these drug companies have, and so, are afraid of angering them.
The reasoning is simple ~ make a vaguely disqualifying statement that hopefully keeps them in the good books.
With bfq-mq, I've encountered no desktop freezing under heavy I/O.
If Linus doesn't put his trusted submaintainers into line, they'll think they can violate core rules of kernel maintenance ~ something as bad breaking userspace.
Linus was right to reply exactly the way he did for such breakage.
There's nothing terrible about reprimanding someone you trusted, especially in front of everyone else.
Helps to tell people to not repeat this level of mistake.
Basically, Eric might be forced to go through others, who will examine his work for pulling quality.
If Eric can prove that he's changed for the better, Linus may well start pulling from him again.
Linus isn't some evil dictator ~ he's just trying to make a point that quality matters.
He was both polite ~ yet criticizing. His expressed his annoyance in a great way.
"Complete garbage" is polite for Linus, compared to his old style. Still brutal, yet effective.
Linus is something of genius when it comes to criticism, whether he's swearing and venting, or coldly and bluntly saying the above to make a point.
What I meant by attitude is exactly what you meant ~ the nonchalant attitude towards breaking userspace, and thinking that it's okay if no-one notices.
Which is when Linus gets the most pissed of all.
Linus was polite, yes, but he expressed his anger and disappointment in a great way. Feels more brutal than his old style, actually.
Actually, instead of hot like before, this Linus is cold. Instead of raging, he coldly expresses his disappointment. In some ways, this feels more brutal than his old style.
Criticizing the mistake as "complete garbage" is great. You don't even need to read anything more to sense Linus is annoyed like he always is when shit hits the fan like this.
Hmmmm ~ can you elaborate on why you think that this is the case?
He's just more choosy about his wording.
Nevertheless, he gets his point across very well:
> Yeah, this is complete garbage.
> Eric, your behavior is entirely out of line
> There are no excuses.
> I will not take any pull requests from you until you have made it clear that you comprehend this very fundamental issue.
Now, Linus may not be explicitly swearing ~ but it comes across in the very same annoyed manner.
Best burn here is him flatly telling Eric that he won't be pulling anything from him until he fixes his attitude.
Fructose over-consumption -> insulin resistance -> diabetes. Heart disease follows.
Cholesterol is just the scapegoat for fructose over-consumption's horrifying effects. Cholesterol is used by the body to try and patch up all of the damage it causes. Cholesterol is used almost literally everywhere in the body, from hormones, to cell linings, etc.
They're often partners in crime, when it comes to subjects not well understood. Especially with something as fragile as DNA.
Cross-breeding allows nature to combine things that fit together in all of the right places. And we just don't know how that even happens, or why. We don't understand nature's algorithm for DNA. No even the tip of the iceberg.
Sure, nature isn't always correct, but does thing properly 99.999% of the time. And that's good enough.
It is utterly incomparable to GM done by humans ~ genes are inserted, but the results are not equivalent to what is done by nature, because we don't understand DNA enough to know where we should be placing the inserted DNA, so that things don't massively fuck up inexplicably somewhere down the line.
Scientists are highly fallible, and prone to making errors, as well as being corruptible by politics and corporate greed.
DNA is ridiculously hard to understand, and it continues to defy current theories.
So, messing with DNA at this time is extremely dangerous, due to just how incomplete our knowledge of DNA is shown to be, and just how fragile DNA is in terms of resilience to random changes.
The OP is case in point, as to where we currently are.
And that's why the OP is a bit horrifying.
DNA's compiler seems to love undefined behaviour ~ probably because the DNA writers knew precisely what to do, without errors.
Undefined behaviour? Whatever ~ creativity ftw!
So, life is greatest and laziest hacker, confirmed, lol?
DNA is the most fucking complex and complicated programming language. We have barely any understanding of how the whole thing hangs together, let alone how it's parsed and written, and how it all translates from stem cells to whole organs, an immune system, the complex interrelation between organs, the nervous system, the whole gamut.
And that's not even touching on the nature of mind and consciousness in relation to the body, a perhaps even more enigmatic mystery than the whole story of DNA itself.
It's one of the few ways to ensure privacy between two people who trust each other.
It completely kills any horrible car sickness I get from any small motions.
It's dangerous to tinker without a truly full knowledge of what one is doing.
We may understand a lot, but nowhere near enough to be able to confidently edit DNA, and know that it won't causes a ton of unforeseen issues down the line.
We don't know what we don't know ~ that is, as much as we like to believe that we understand a lot about DNA and how it works, odd things pop up all the time that prove us wrong. I dare say that there are far deeper mysteries about DNA that we have no current understanding of.
> Nature does not ‘know how’ to make it work 99.99% of the time. Nature very frequently aborts pregnancy’s when any number of things go wrong. Getting all the way to birth is a huge checksum that validates the majority of critical DNA.
This is merely an example of nature getting it right ~ abort if there are serious issues.
> Which gets it the larger point. Evolution focuses more on species propagation than individuals.
It is about both ~ the individual matters most ~ species propagation doesn't even register in importance to a majority of individuals. Having children does. They're subtly different ideas.
DNA looks mightily like an extreme and profoundly complicated, complex piece of programming, with unnecessary redundancies removed, and useful redundancies left in, as well pieces of code that call lots of other pieces, as well as being called by others.
If the genome is analogous to a computer binary... we don't understand the file format, and how it is read and interpreted.
Nature knows far-and-away better than we do how to make it all work 99.99% of the time, with occasional errors due to radiation, poisoning, interbreeding being accounted for so that things don't get out of hand.
Well, these assumptions held... until we intelligently stupid creatures came along, using our intelligence to create dangerous tools that are most abused by those least worthy to wield them...
Google is the one creating a web essentially bound to whatever Chrome does, supports, or doesn't support.
With 7nm, Intel seems to have taken a more sane approach, but their 10nm failures and setbacks costed them a lot.
In practice, TSMC's 7nm node is actually functional, and producing working chips.
Intel's 10nm... well, is garbage, because they were overconfident.
Now Intel has to either rework their 10nm node, after wasting many years of work on nothing, or just jump straight at 7nm, which seems equivalent to TSMC's 3nm node plans.
Intel has created a situation for themselves where they seem to have forgotten how to care about the purpose of innovation.