HNHacker News
TopNewBestAskShowJobs

Perenti

632 karma · joined January 23, 2019

submissionscomments
Perenti··on Ask HN: How do I know that I am autistic?
You know if you're autistic because you have a report of assessment performed by a qualified professional.

If you want to know if you're autistic there are tests psychs can do.

Perenti··on Fentanyl vaccine tested in rats
Forgoing surgery in my case would be rather fatal.

One catch is that if you're undiagnosed with some problem like mine (Brugada Syndrome) you might get the vaccine before you know that's a bad idea. I have, in the past, been dependent on opioids thanks to my broken body, and yeah, getting off them has challenges. But I think the key is WHY some people like them so much. There's something a bit off when the aim is to take so much you vomit but don't die, which I'm given to believe is the "ideal" recreational dose.

Perenti··on Fentanyl vaccine tested in rats
Fentanyl (and the derivative the vaccine works on) have very short half-lives, which is ideal for _minimal_ dosing during surgery. Any drug that lengthens the QT interval, or fucks with the S wave will bring about catastrophic heart failure in people with conduction channel issues. The only time alternative anesthetics are given to me for example is to induce heart failure in order to test new leads.

I find the idea of a vaccine that makes therapeutic drugs fail to work quite scary personally.

Perenti··on Fentanyl vaccine tested in rats
Not really. There are people for whom Fentanyl is the only real choice for use _during_ surgery. I'm one of them, and I don't want doctors mucking about inside my chest without ample pain relief.
Perenti··on Fentanyl vaccine tested in rats
What about twilight anesthesia? With my cardiac problem, I can't have general anesthetics, but I can have Fentanyl/Midazolam to sedate and numb up a bit. Saying "it's specific to fentanyl" doesn't help those for whom fentanyl is a life saving drug.

The reply above that the real issue is WHY Americans like fentanyl so much is on the money in my opinion.

Perenti··on American Express: your last name is improper
Reasonably common and significant name in Kampuchea. One of the things these lists reveal is the depth of cultural bias out there.
Perenti··on Right and wrong: ten choices in language design
I don't believe this is a fair comparison of choices in language design, as it almost ignores Smalltalk and relatives. Almost all the "issues" of language design listed don't exist in Smalltalk (and others), and when he discusses Class methods he says it works but __seems__ heavy handed. That is not analysis, it's opinion.
Perenti··on PayPal’s updated acceptable use policy [pdf]
It means whatever it wants in "certain" contexts. I've never seen the word "certain" used to imply so many vague, uncertain things before.
Perenti··on Whois: Fragile, Unparseable, Obsolete
IPs are shared by many machines these days, in particular CGNAT bundles many machines in potentially very disperse locations together. You can't identify the source of DDOS by whois in that case.
Perenti··on Nuclear-Powered Cardiac Pacemakers
I have an ICD, and have had to have two lead revisions, once when the lead failed to implant, and the second when it cracked. My resting pulse is 100bpm, and the device overpaces me if I exceed 140bpm (unless having sex, when it kicks in at 220bpm. Is this so I'll die happy?). So in ten years my leads cop at least 500 million bends. Since my device does cardioversion and defibrillation there's no way a wireless implant in the atrium and ventricle will work.

The doctors keep quoting figures of how reliable this tech is, but I've had 3 procedures due to device failure in the last 5 years.

Perenti··on The Evolution of THC Vape Cartridges
I bought a hemp t-shirt in the early 1980s. I wore it up to the early noughties. Hemp clothing outlasts cotton and most synthetics in my experience. So is it better? Depends.
Perenti··on How the Ballpoint Pen Killed Cursive
We had to use nib-based pens until 1st Form, when we were allowed biros. Suddenly my clothes were no longer soaked in ink, my pages were no longer Rorshach inspired artworks.

And my writing, for the first time ever, was legible. This is what killed cursive, it's bloody hard to read.

Perenti··on Photos of chickens, taken by chickens
We'd feed birds crab shells every second day for a week or two. When the hard boiled eggs were cut open we'd have concentric red/orange rings in the yolk.
Perenti··on Photos of chickens, taken by chickens
I grew up on an organic, free-range poultry farm in the 70s. The current definition of "free range" supports up to 100 full grown birds per m^2. The treatment of battery hens and factory farmed poultry is an obscenity, in my opinion.
Perenti··on The Power C Compiler
What a blast from the past!

I loved Power C. The paper manual was quite amazing - imagine all the man pages, but informative with examples and superbly written. I kept using that manual for years until it quite literally fell apart, purely because it was so good.

Perenti··on Study confirms superior sound of a Stradivari is due to wood treatment (2021)
And if done changes the tone of the instrument. Is not unknown amongst the acoustic guitar players that you can improve the tone by subjecting the instrument to recorded music for a _long_ time.
Perenti··on Study confirms superior sound of a Stradivari is due to wood treatment (2021)
I've owned several acoustic guitar over the last 50 years and guitar tone changes over time, based on how much music it hears/makes. If you take a midrange guitar and put it on a stand near a speaker, and subject it to moderately loud music for days on end the sound _does_ change for the better. This is a commonly observed affect. Other guitarists have mentioned it to me.

Now maybe op didn't word the physics and material science precisely, but what they describe is real. Perhaps you have a better explanation for a commonly observed phenomena.

Perenti··on Ask HN: Did YouTube just change their algorithm?
Does that "Not Interested" button do anything? I get continually spammed with recommended Minecraft videos. I've never watched one, have never played the game, and click on "Not Interested" for the suggestions, and still get spammed.
Perenti··on Expert: Monkeypox likely spread by sex at 2 raves in Europe
My post was downvoted. Here's where the numbers are: https://www.unaids.org/en/resources/fact-sheet

It says:

New HIV infections have been reduced by 52% since the peak in 1997.

    In 2020, around 1.5 million [1.0 million–2.0 million] people were newly infected with HIV, compared to 3.0 million [2.1 million–4.2 million] people in 1997.
    Women and girls accounted for 50% of all new infections in 2020.

The assertion that 86% of new infections are in the gay community is false
Perenti··on Expert: Monkeypox likely spread by sex at 2 raves in Europe
I'm pretty sure the vast majority of new HIV cases are in Africa, amongst heterosexual clients of sex workers. Maybe your 86% figure might apply in countries like the US where health care is a privilege and not a right.

Your last sentence reminds me that COVID was going to be over by Christmas 2020...

Perenti··on Expert: Monkeypox likely spread by sex at 2 raves in Europe
I'm pretty sure that HIV is more prevalent amongst heterosexual people than gay men. Unless you are saying that most Africans are gay, that most SE Asians are gay, and that most Papuans are gay (hint - they're not).

In most 1st world nations your assertion _may_ be true, but in Australia at least HIV is most prevalent in the needle sharing community.

Perenti··on MasterCard to launch biometric checkout tool for retailers
Hmmm.... so what is recorded to enable later verification? Saved video? Saved eigenvectors/values?

And What Could Possibly Go Wrong?

Perenti··on Australia's ID systems 'deficient', unfit for online: review
There's a link in the article to the PDF released under FOI. I worked on some of the failed id card schemes mentioned in it, and based on what sections are redacted, along with the input from Home Affairs and Homeland Security, as well as the Australian Federal Police suggest this is yet another political attempt at control.

Please read the pdf if you've any interest at all in this.

I can't see how this model really helps anything except the old Australia Card agenda. And we know Australians are _very_ uncomfortable with that one.

I think the redactor missed something as well, look at the appendix with the graphs from KPMG. They predict this card will have higher uptake than the Israeli one does. That means carrying the card would be mandatory, and that's not Ocker at all.

Perenti··on Cats learn the names of their friend cats in their daily lives
"I want that done by the time I count to one" terrifies 5-7 year olds.
Perenti··on A wild turkey is attacking people in D.C.
Here in South East Queensland we have Brush Turkeys, which are megapodes. Males who can't get a mound travel in mobs and gang rape chickens. My good friend Shane the vetinarian treats traumatised chickens every year.

Australia. Where a bird that _doesn't_ want to kill you is a sex pest.

Perenti··on Runcible is a circular, Firefox OS smartphone with a wood case
Page is 7 years old, seems this company and product do not exist.
Perenti··on Linux distributions are becoming irrelevant (2017)
I find it personally amusing that the author is/was a Gentoo developer. Since 1995 I've played with most distros, and used 2 or 3 or so (deb based). The only distro I repeatedly gave up on during installation was Gentoo. This is probably a measure of my incompetance, but highlights, IMHO, why multiple distros existing is important.
Perenti··on Mapping the “catscape” formed by a population of pet cats with outdoor access
I don't think these numbers are comparable. To the best of my knowledge one cow can fill many cans of cat food, whilst a cat may eat many geckos in a day. Similarly I may eat an entire rabbit in a day, but it'll take a while for me to eat a sheep.
Perenti··on Psychology “incompatible with hypothesis-driven theoretical science”
Yes!! I think it is to justify grant applications. Trouble is they're using stats as weasel words and the people who approve the grants have no idea.
Perenti··on Antidepressants are not associated with improved quality of life in the long run
I live with depression, and have taken SSRI and SNRI medication for about 30 years. It took a very long time to find the drug and dosage and dosing regime that works for me. I still get way down, but not _too_ dark and since going on current meds 3 years ago have had no issues with suicidal ideation. Depression is a complex set of problems, and it is in my experience unreasonable to expect a "complete cure in a box" when dealing with Major Depression. In my case there is little doubt that my current SNRI is life extending.

To be honest, I sometimes think that maybe pointing out how weak the evidence is for AD meds in general may dissuade some people from trying them - and they may work, as may a placebo. I really appreciate the way you worded this, it's really rare to find a balanced and informed opinion like you have shared.

← PreviousPage 8 of 10Next →