John7878781

Yep. Sequence-to-function models are still very limited. AlphaGenome Atlas, despite the flashy branding, is unlikely to provide significant benefit to researchers.

I don’t think Demis played a big role in this. It was mainly Ziga Avsec who developed Enformer (the first actually decent sequence-to-function model), and then AlphaGenome.

People are upvoting this because it has the “Alpha______” prefix. Meanwhile, everyone in the field of genomics knows that AlphaGenome provides essentially zero improvements over the previous SOTA, Borzoi…

> If it doesn’t make sense for people to say “vegan except for chicken”, “vegan except for beef”, then why on earth would it make sense to say “vegan except fish”?

I don't know why you take offense to someone saying "vegan except for beef" or "vegan except for fish." There is nothing inherently wrong with these statements. It just depends on whether you view veganism as a lifestyle or as a diet, which can vary depending on the context. In the context of a nutrition study, we are obviously talking about the diet, not the lifestyle.

I assume you mean that the study should not have said “vegan diet” and instead should have said “plant-based diet.” In that case, I agree with you. But don’t direct your anger towards me; direct it towards the authors of the study!

If someone adopts a vegan diet purely for health reasons, are they not a true vegan? They haven’t accepted the moral framework that killing animals is wrong.

Should the study filter out people who eat entirely plant-based for reasons other than ethics. because according to you, that’s not a true vegan diet.

I think you are largely correct that veganism is a lifestyle, not a diet. But in the context in which my comment was made, it was perfectly reasonable for me to say “vegan except for fish,” because the study was analyzing veganism as a diet, not as an ethical lifestyle.

I actually prefer not to call myself a vegan IRL both because of the issue you’re describing and because veganism is (rightfully) associated with having a toxic and intolerant culture. The only reason I said “vegan except fish” in my comment is because the title of the study used the word “vegan” and because the study was talking about veganism in a purely dietary/scientific lens, not an ethical one. I think this was a pretty reasonable thing to do.

in those situations, especially if the business is unresponsive, i just keep charging back until they stop. if i can subscribe easily, i should be able to cancel just as easily :)

Sorry for not being perfect like you. For ethical reasons, I do not consume dairy or meat (except for fish). The vegan community should be more open to other perspectives, especially when someone is actively making an effort towards reducing harm.

Vegan Puritanism is totally antithetical to our collective goal of reducing animal suffering. Rather than being motivated by the prospect of claiming moral superiority, our goal should be to help the animals.

I am vegan except for fish, and find it works really well. Sardines are awesome!

I would be shocked if Cybercabs solely rely on GPS for positioning. I imagine they look at their surrondings, etc.

This is what Google needs to do and is probably why Demis has stepped back a bit

You should know: AA index is only 61. Pretty surprised it’s that low.

Try gpt 5.6 Luna max

Translating CUDA kernels to ROCm (or any other ecosystem, tbh) is going to become trivially easy with AI. Not saying that code is the only glue that Nvidia has when it comes to their ecosystem, but it’s certainly a large part of it.

That's kind of sad. I miss being an OG em dash user.

> Nothing is a bigger red flag than a wall of text with perfect grammar and punctuation.

So you're choosing to punish well-written text?

It's hard for me to trust this PDF when there's literally a typo directly under the author's name: "analyitcs"

Luna max is all I use. In my experience, it works really well for overnight tasks.

In my experience, Gemini excels at explaining new concepts clearly and intuitively. Much more so than other models.

I have always had a very low blood pressure, below what's considered "normal." I never feel dizzy when standing up, though. Is this still a risk factor for dementia?

Goal: Fix the world.

GPT: Sure! <thinking> To start, we'll need to eliminate the human race.

Frankly, I haven’t been impressed with AlphaGenome at all. What use cases have had good results for you?

IMO, out of all the products with the “Alpha_____” branding, AlphaGenome is the most underwhelming.

Interestingly, you're actually more likely to be flagged as AI if English is your second language.

Given that intelligence is ~60% genetic, if well-educated people are having kids less, then are we going to start getting dumber?

Abolish SSNs.

AI mode isn't that terrible.

This sounds completely absurd. What's stopping me from starting up a bunch of LLCs or Trusts to rig the vote?

Run the following two commands in your terminal while inside the ~/Antigravity-x64 directory:

sudo chown root:root chrome-sandbox

sudo chmod 4755 chrome-sandbox

They work for me.