I had spent a lot of this time approaching local design agencies and web dev studios (of which there are a lot in my area) for internships and the like, rarely ever met with a response, let alone a "thank you, but no," so I kept plodding away.
Eventually, someone responded to my enquiry, a small design agency with a few fairly big clients, they offered me an unpaid internship working 3 or so days a week to build up some experience. As much as I came to learn they were exploiting me (I was there well over a year, eventually working for minimum wage), I still do owe them a hell of a lot. Getting back into the swing of things, doing something that I loved gave me my confidence back, I learned to trust my skills and that I am good at what I do.
From that point on, literally every changed in my life. I came off the anti-depressants, found a new girlfriend, got a new house and now have a new job making decent money for a company I really enjoy. As much as I may bitch and moan about how that agency took the piss so much with me, the chance that they took on me turned my life around.