The problem, or the balance that must be struck, is that it's hard to innovate without being surrounded by other innovative people. You need a city with a critical mass of innovative, talented people and a low cost-of-living. California in the 1970s had that. I don't know what the 2013 analogue is, or if it's even in the US. The Midwest would qualify, but it's hard to raise any kind of money (VC, bank loans) out there.
When real estate is expensive, money dominates peoples' lives-- even seemingly wealthy people who still don't make enough to raise a family. When it's cheap, people focus on other things and money is just one thing in it.
I'm ideologically against expensive real estate. I think that the government should buy, build and own about 60% of housing and set the prevailing rent per square foot. Rich people will still have the ability to buy property and to rent or own nicer private housing, but the basic prevailing rate will be set. This actually doesn't bring along the negatives of price ceilings (shortage) because the government can also build more housing and transportation infrastructure to increase available supply. I think we should hold the government responsible for that. No one should have to pay more than 1/4 of post-tax income to live within 20 minutes of work.
The reason New York is expensive is that people like me-- ambitious, hard-working, extremely capable-- are able to find jobs here. People like me make the fucking city great. For each person like me, there are 9999 who want to be around (or employ, or exploit) people like me and they drive up the fucking rent. Instead of benefitting from our contribution, however, we get charged for it when we pay these enormous housing costs. We should be rioting in the fucking streets over this.