I'm currently living in Auckland, New Zealand, which by NZ (and world standards I think, though can't cite anything off hand) is quite expensive, but myself and my girlfriend have been contemplating moving to Sydney, Australia, a city which is one of most expensive in the world but where we would both be paid more. The cost of living there makes it a complete non-starter if you're not just wanting to work full time - and then trying to eek out a pleasurable life at the weekends.
I currently contract 3 days a week to support myself while working on my startup and trying to fit in some time for music as well in the other 4 days (and try to get relaxation each week too). The money I make wouldn't last very long in Sydney or any world city for that matter, I guess that's where the VC is supposed to kick in, but if it doesn't then you're in trouble.
If it's one thing I've worked out recently, full time, 40 hour week style employment is the enemy of me being able to pursue any sort of interesting side project, I'm sure it's similar for others. It's a realisation that, now I've had it, I can't imagine ever working under those conditions on anything but my own projects. High costs of living such as those in SF and Sydney (and even Auckland) can necessitate such income just to live with a modicum of dignity however, and then trap you with dining out at weekends and such, resulting in not actually achieving any progress on the projects that matter most to you. Worst of all this is the debilitating feeling that socialising and being a functional human being is preventing you from achieving your goal.