Suk doctors are theoretically safer because of their imperial conditioning, but even that can be tampered with, as we see with Dr Yueh. This is a central problem in Dune: Whatever you depend on will gain power over you (or whoever controls the thing you depend on). Dependency on spice, on truthsayers, on mentats, or on thinking machines - even specific relationships. All of these are systemic vulnerabilities and therefore potential attack vectors in Dune.
(Edit: Suk Doctors get imperial conditioning, not mentats)