Suk doctors are theoretically safer because of their imperial conditioning, but even that can be tampered with, as we see with Dr Yueh. This is a central problem in Dune: Whatever you depend on will gain power over you (or whoever controls the thing you depend on). Dependency on spice, on truthsayers, on mentats, or on thinking machines - even specific relationships. All of these are systemic vulnerabilities and therefore potential attack vectors in Dune.
(Edit: Suk Doctors get imperial conditioning, not mentats)
Dr Yueh was not a mentat, but a suk doctor who was subject to conditioning. (Which was broken by the Piter de Vries, via the pain amplifiers applied to his wife, Wanna.)
Paul himself was being trained to be a mentat, and there were no hints of conditioning there, neither with Paul, Hawat, or de Vries (albeit he was described as a "twisted mentat", whatever that means).
That doesn't necessarily mean they were grown in tanks, though, they could just have been "groomed for purpose" in the same way the Tleilaxu's matriarchal counterpart the Bene Gesserit did.
(The Tleilaxu are to me a very obvious stand-in for "patriarchy": there are a few men ruling over a genderless, fluid workforce, and women are literally just birth machines.)
Is it also true that Fremen are canonically descendants of Zensunni practitioners, which is a mix of Zen and Sunni Islam
Many other restrict machines, and the dogma is encoded on a religious text called the Orange Catholic Bible. And, this might be a big jump but, some of the specific anti-machine quotes are similar to Matthew 12:31-32 IMO
Dune is very much about systems of power and oppression, the obvious and less obvious forms they take, and the way they transcend and direct individuals. Even when the individuals are almost omnipotent - in theory.
The whole point of Dune is that these systems are human, but have an independent life of their own.
The narrative is about modes of human supremacy, and a jihad against AI isn't just some optional world building, it fits the narrative perfectly.