Incompleteness is inherent to our understanding as the universe is too vast and endless for us to ever capture a holistic model of all the variables.
Gödel says something specific about human axiomatic systems, akin to a special relativity, but it generalizes to physical reality too. A written system is made physical writing it out, and never complete. Demonstrates that our grasp of physical systems themselves is always incomplete.
An environment living in Conway’s Game of Life could be quite capable of hypothesizing that it is implemented in Conway’s Game of Life.
Systems can hypothesize about themselves but they cannot determine why the rules they can learn exist in the first place. Prior states are no longer observable so there is always incomplete history.
Conway's Game of Life can't explain its own origins just itself. Because the origins are no longer observable after they occur.
What are the origins of our universe? We can only guess without the specificity of direct observation. Understanding is incomplete with only simulation and theory.
So the comment is right. We would expect to be able to define what is now but not completely know what came before.
"The universe is not required to appeal to your aesthetic tastes."