I work on a large Django codebase at work, and this is true right up until you stray from the "Django happy path". As soon as you hit something Django doesn't support, you're back to lego-ing a solution together except you now have to do it in a framework with a lot of magic and assumptions to work around.
It's the normal problem with large and all-encompassing frameworks. They abstract around a large surface area, usually in a complex way, to allow things like a uniform API to caches even though the caches themselves support different features. That's great until it doesn't do something you need, and then you end up unwinding that complicated abstraction and it's worse than if you'd just used the native client for the cache.