I think the baggage goes both ways - Django has the advantage of being a "complete & proven recipe" vs. Node where you try to lego-together an app out of dependencies that have deprecation warnings even in their latest versions.
I work on a large Django codebase at work, and this is true right up until you stray from the "Django happy path". As soon as you hit something Django doesn't support, you're back to lego-ing a solution together except you now have to do it in a framework with a lot of magic and assumptions to work around.
It's the normal problem with large and all-encompassing frameworks. They abstract around a large surface area, usually in a complex way, to allow things like a uniform API to caches even though the caches themselves support different features. That's great until it doesn't do something you need, and then you end up unwinding that complicated abstraction and it's worse than if you'd just used the native client for the cache.
I guess if you write a lot of custom code into specific hooks that Django offers or use inheritance heavily it can start to hurt. But at the end of the day, it's just python code and you don't have to use abstractions that hurt you.
Could you be more specific? Don't get me wrong, I'm well aware that npm dependency graph mgmt is a PITA, but curious where you an into a wall w/ Node.