C compatibility / extension compatibility - nope. First, it is an issue of limited resources. Add more devs to pypy team and compatibility bugs gets fixed. Second, aren’t people writing C extensions due to python being slow? Make python fast - as pypy - and for some cases native code won’t be that crucial.
So I don’t see a real issue with pypy that could not be solved by simply moving all the dev efforts from CPython.
So are there political, personal or business issues?