Yes.
First is startup time. REPL cycle being fast is a big advantage for development. From a business perspective, dev time is more expensive then compute time by orders of magnitude. Every time you make a change, you have to recompile the program. Meanwhile with regular python, you can literally develop during execution.
Second is compatibility. Numpy and pytorch are ever evolving, and those are written a C extensions.
Third is LLMs. If you really want speed, Gemma27bqat that runs on a single 3090 can translate python codebase into C/C++ pretty easily. No need to have any additional execution layer. My friend at Amazon pretty much writes Java code this way - prototypes a bunch of stuff in Python, and then has an LLM write the java code thats compatible with existing intra-amazon java templates.