Hacker News Reader

I don’t think you multiplied quite right. An 80-kg person would need 400mg, which would take 40g of shrooms if potency is 10mg per dried gram.

That would still be 10 times larger than a regular dose. I think that would make most people seriously ill, not to mention the mental effects. One must assume that mice respond differently than humans.

View on HN

Yeah someone also brought up that its not a linear scaling. https://pmc.ncbi.nlm.nih.gov/articles/PMC4804402/

And the study calculates it a 5mg for rats as 25mg for humans.

It's 5 mg/kg (or 15 mg/kg due to faster metabolism) for rats, and 25 mg (not per kg!) for humans. To be clear, 25 mg is a completely normal dosage that has been used in previous human studies.

Reply on news.ycombinator.com