Well your perception of time would certainly be longer at that dose. Probably feel like you've lived for centuries.

I don’t think you multiplied quite right. An 80-kg person would need 400mg, which would take 40g of shrooms if potency is 10mg per dried gram.

That would still be 10 times larger than a regular dose. I think that would make most people seriously ill, not to mention the mental effects. One must assume that mice respond differently than humans.

After a few days, such a dose would likely become imperceptible in “healthy normals.”

Your two statements contradict

If 1g of shrooms has 5mg psilocybin, to get a dose of 5mg/kg would be like 75g for an average man (still feels very high but nowhere near 1kg)

Ah yes, a proper morning routine. A bit of coffee, exercise, becoming one with the void…

"First, we sought to model high-dose used in a clinical study for chronic pain, where patients were administered a psychedelic dose (25 mg) of psilocybin. Using the standard allometric scaling method, a human dose of 25 mg of psilocybin translates to a mouse dose of approximately 5.14 mg/kg."