Psilocybin treatment extends cellular lifespan, improves survival of aged mice
news.emory.edu
news.emory.edu
I actually liked it more because it was animated. Trippy worlds are more fun to see animated.
Edit: Did the math wrong.
That would still be 10 times larger than a regular dose. I think that would make most people seriously ill, not to mention the mental effects. One must assume that mice respond differently than humans.
And the study calculates it a 5mg for rats as 25mg for humans.
If 1g of shrooms has 5mg psilocybin, to get a dose of 5mg/kg would be like 75g for an average man (still feels very high but nowhere near 1kg)
At 25mg, thats 2.5g first month and 7.5g monthly afterwards. I wonder if the effects are the same with monthly injections vs daily though.
First, please correct me if I'm wrong, but is it possible that the article made a mistake either in the dosages or the substance that was administered? It calls 5mg/kg of psilocybin a low dose. To me, this is an insanely high amount if we're really talking pure psilocybin (not psilocybin mushrooms). Johns Hopkins reported treating people with (high) therapeutic doses of psilocybin (not mushrooms) of between 20mg and 30mg per 70kg. In strictly mushroom weight, that's anything between 3g and 5g of dried cubensis. If the article is correct, what they administer those mice is the equivalent of giving a 70kg human 350mg of psilocybin (as a low dose lol), or about 50g-60g of dried mushrooms to munch on? I hope the article made a mistake, rather than someone from the research team misread the recommended dosage.
EDIT: According to my limited search, a 12-weeks old lab rat could weight anything between 0.25-0.5kg. At 5mg-15mg/kg, that's approximately 1.25-2.50mg for low doses of psilocybin and 3.75-7.5mg for high doses. I don't find this as outrageous as originally. It could work if we take into consideration that brain size is probably a more significant factor than body mass.
Second.
> this study suggests that psilocybin impacts multiple hallmarks of aging by reducing oxidative stress, improving DNA repair responses, and preserving telomere length. Telomeres are the structured ends of a chromosome, protecting it from damage that could lead to the formation of age-related diseases, such as cancer, neurodegeneration or cardiovascular disease. These foundational processes influence human aging and the onset of these chronic diseases.
Unless I misunderstand what I'm reading, I wouldn't say that it's really psilocybin (the chemical) that's responsible. It's the taking then subsequent tripping. It's now known that without the trip, no benefit. If my intuition is correct, it could be that LSD along with a few other psychedelics (and associated practices) might affect you in a similar way over the long run.
Some comparisons between animals and humans just aren't compatible with understanding dose and volume. Some smaller animals eat their weight in food, I just wouldn't recommend basing your own dietary fiber intake on that.
Why would "tripping" be the cause of reduced oxidative dress, DNA repair responses and preserving telomere length?
so we take their 'cures'
while they suppress our medicine.
Alllll that text just to say "grind/soak the shrooms in lemon juice first and it will hit harder and last shorter".
Meanwhile using the lemon tek the experience is consistently around 4 hours in length.
For me, this is the ideal trip length. I'm very rarely looking to spend my entire day tripping.
Lemon-trek is supposed to help by 1. griding it to a powder, and 2. Putting it in a lemon solution to help do some of that breaking down process
I am not sure where to get psilacetin from, not anymore at least. It was readily available 2 years ago (was cheap as hell, too), but I don't know about today.
I did 4-aco-dmt multiple times in high school.
Luckily, I just tripped and was grateful to be alive on the other side.
At least half, if not 15 out of 20 of my friends went completely into psychosis and a good majority of those people had persistent negative symptoms for weeks after.
I also considered making my own. But then I thought that rolling your own chemistry could prove to be more fatal than rolling your own cryptography.
it also goes the other direction: Men in their 20s and 30s get hurt doing the same risky activities they did in high school (rock climbing, basketball, soccer, etc) resulting in lower back pain, damaged hands, etc.
I'm a runner, but yea also a bit injury prone, especially on the knees.
Whereas non-wet activities have similar requirements to my regular laundry management
https://en.m.wikipedia.org/wiki/Disability-adjusted_life_yea...
Thanks for helping people understand this concept!
Am not kidding. I hated exercise, I still hate it, but it objectively makes everything else so much better I keep at it.
There are simple and effective protocols. You don’t need to be ”in to it”. You don’t need to buy extra equipment (necessarily) nor do you need purchase anything from anyone (unless you want to).
Running, pushups and kettle bell swings are enough (with a good strategy). Having a daily stretching/mobility routine is advisable the older you get.
Just do it! If you think it will totally suck, it probably will! If the question ”what are you training for” irritates you it sure as hell will keep irritating. There are _zero_ lifestyle things you need to buy into. But it’s medicine. Pure medicine.
You're the type of person I'd follow advice from because I hate exercise too, lol.
If you have very little exercise from recent years, I really recommend finding a local personal trainer, explain you want a bare minimum personal program and start from there.
Once you know what your body can do under supervision you can think about how to develop routines that last your life.
Personally I bought some courses from GMB fitness for mobility and for some kettlebell stuff read the book ”Simple&Sinister” whose basic program I did for a year, and then started doing ”The quick and the dead” program from the same author. Now - the books are a bit weird and the motivational narration may be offputting but the exercises seem legit and effective.
I don’t know if any of the above is usefull at all for anyone else. But the basic science sort of goes you need some basic aerobic exercise and some resistance training. Free weights like kettlebell seem to offer best bang for buck since the basic exercises actually train a lot of the muscles at the same time.
The ”lets isolate the muscle groups and pinpoint these exercises” regimen might have it’s use but’s imho it’s sort overcomplicating the basic equation if you really are not training for anything particular and have no handicaps from injuries.
I understand the deadlift is a super effective and simple technique but I hate going to gym and don’t have space for anyhting else except kettlebell.
Like Scott Hanselman tipped - plan a routine that gives you least amount of opportunities for excuses.
I wish the same focus was given to weight loss, smoking, etc. No one really cares about living an extra 10 years from 70 to 80 if it means giving up 40+ yesrs of enjoying bad habits.
Exercise is especially neat because there are enjoyable ways to do it
It’s the same thing, right?
That is, exercise may not necessarily make your life longer, but has a good chance of making your life higher quality.
Similarly, bad habits can shorten your life, and even if it doesn’t, will most definitely make your life lower quality (eventually).
Or maybe that’s the point you were making?
Instead, I think we need to focus on "you'll feel better, like right now".
Speak for yourself...
Finally, exercise is not only gym, hiking, climbing, running, the list is endless
There are plenty of fun ways to exercise where you won't be stuck in a gym using a machine or just repeatedly lifting heavy things.
i have worked out for atleast 3 times /week for last 30yrs. It has always been my fav part of my day.
https://hn.algolia.com/?dateRange=all&page=0&prefix=true&que...
Vegetarians live 10 years longer than meat-eaters.
Some studies indicate that vegetarians may live an average of 6 to 10 years longer than meat-eaters, with some studies showing even larger differences for those who switch to a plant-based diet early in life.
Vegetarians are generally more conscious of their health than omnivores. Because you have to realize that omnivores includes the vast majority of people.