The fight increases the faster/further you jump around the circle of 5ths. The 12TET fret spacing aligns octaves and 5ths with JI, so if you tune for a JI `I` chord, your other chords will be internally JI but only your `V` chord will be spaced perfectly from the `I` chord. The other chords will be closer to perfect JI the closer they are to `I` on the circle of fifths.

This microtuning isn't perfect in theory, but it's a favorable compromise for a lot of western music, especially for legato strumming where the inter-string intervals are heard more often than the inter-fret intervals.