Hacker News Reader

This paper? https://pubmed.ncbi.nlm.nih.gov/38498958/

Only surveyed 20 people, subjective rating of effects, no word on existing tolerance in this cohort. Also double blind is pretty impossible to actually do when it is in terms of a psychoactive drug. Imagine testing drunkenness and having a cohort drink water, how useless that would be as a placebo, as people would know immediately they have not been given the drug and are still feeling quite sober.

View on HN

Double blind in this instance meant THC distillate with the terpene or without to avoid that standard issue.

Double blind means the researcher doesn't know what they are giving to the subject. They still ran a placebo.

"Methods: Twenty healthy adults completed nine, double-blind outpatient sessions in which they inhaled vaporized THC alone (15mg or 30mg), d-limonene alone (1mg or 5mg), the same doses of THC and d-limonene together, or placebo; a subset of participants (n=12) completed a tenth session in which 30mg THC+15mg d-limonene was administered. Outcomes included subjective drug effects, cognitive/psychomotor performance, vital signs, and plasma THC and d-limonene concentrations."

The only comparison of note being between THC only and THC+15mg d-limonene.

Reply on news.ycombinator.com