The evidence is coming out now that real experiments are easier to do.
See Russo’s latest double blind work on distillate + specific terpenes.
See Russo’s latest double blind work on distillate + specific terpenes.
Only surveyed 20 people, subjective rating of effects, no word on existing tolerance in this cohort. Also double blind is pretty impossible to actually do when it is in terms of a psychoactive drug. Imagine testing drunkenness and having a cohort drink water, how useless that would be as a placebo, as people would know immediately they have not been given the drug and are still feeling quite sober.
"Methods: Twenty healthy adults completed nine, double-blind outpatient sessions in which they inhaled vaporized THC alone (15mg or 30mg), d-limonene alone (1mg or 5mg), the same doses of THC and d-limonene together, or placebo; a subset of participants (n=12) completed a tenth session in which 30mg THC+15mg d-limonene was administered. Outcomes included subjective drug effects, cognitive/psychomotor performance, vital signs, and plasma THC and d-limonene concentrations."