I always find it a problem when US roads use a N/S/E/W designation based on their overall trajectory rather than the local direction.

For example, we live south of Santa Fe, but to tell people how to get here [0] we have to say "take I25 North" (because heading out of Santa Fe and away from Albuquerque, the road heads south east, even though its ultimate destination (Buffalo, WY) is clearly to the north. The road signage is consistent, but if you also have a reasonably strong sense of direction, your head can be asking "why am I going south on a north-labelled road" or a variant thereof.