I grew up along US Highway 62 - which I found our recently is the "only east–west United States Numbered Highway that connects Mexico and Canada".[1]
For example, we live south of Santa Fe, but to tell people how to get here [0] we have to say "take I25 North" (because heading out of Santa Fe and away from Albuquerque, the road heads south east, even though its ultimate destination (Buffalo, WY) is clearly to the north. The road signage is consistent, but if you also have a reasonably strong sense of direction, your head can be asking "why am I going south on a north-labelled road" or a variant thereof.
In Texas, I35 runs north and south. But it also splits at one point, creating I35 east, and I35 west, so if you’re going from Austin to Dallas you take I35 east northbound.