If the practical limits of rocket technology don't allow life to much beyond their own solar system then given the vastness of space that would be a good reason why we don't see any evidence of intergalactic civilisations or large feats of engineering. All other explanations for why the universe seems to lifeless seem to rely on elaborate hypotheticals like us being an early civilisation, us being extremely lucky/improbable in other ways, or that alien life is anti-social. But it always seemed to me that the best explanation is probably just that such things are not possible.
I mean there's a chance there's some new physics out there, but you'd think if there was star wars level tech out there (warp drives, etc) then something out there would have built one already and would rather quickly spread outwards...