Unless I'm just parroting truisms here, dedupe is almost never a good idea and compression is a much more common case-by-case.
> So personally I'd encourage messing around (on something non-prod, of course). Measure measure measure! Does it actually make any difference.
100%. So much depends on the particular workload and resources.
> And making backups, even for ZFS backed filesystems. Sacrilege, I know.
Logical backups, specifically. We have seen more than once corruption and data-loss in replicated encrypted snapshots due to bugs in ZFS.