you don't actually want to nuke your IGF-1. it's important for metabolism, maintaining muscle tissue (also important for health in old age), and general quality of life. this is a lifespan versus healthspan thing, sort of like a lesser version of why eunuchs live longer.

we're increasingly seeing that mTOR/PPAR/metabolism aren't great targets for antiaging because you can't square the circle of worse quality of life over those increased years.