I'm not sure suppressing IGF-1 will have the same effect. Two nearby points from the article:

> This is unusual — very few if any other animals have such an extreme lifespan variation within the same species.

> Part of this lifespan disparity comes from the process of selective breeding that “created” these dog breeds.

And from wiki:

> A 2022 review found that both high and low levels of IGF‐1 increase mortality risk, whilst a mid‐range (120–160 ng/ml) is associated with the lowest mortality.[1]

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8844108/

you don't actually want to nuke your IGF-1. it's important for metabolism, maintaining muscle tissue (also important for health in old age), and general quality of life. this is a lifespan versus healthspan thing, sort of like a lesser version of why eunuchs live longer.

we're increasingly seeing that mTOR/PPAR/metabolism aren't great targets for antiaging because you can't square the circle of worse quality of life over those increased years.

I see I'm not the only one who wants to recreate the Canadian House Hippo by starting them out young on Loy-001