Based on the subreddit, which is usually a trash fire, it's what you'd expect I guess? Everyone thinks murder is bad, so we start at that baseline, and from there it's a couple classes of people arguing with eachother: those that are happy to consider san francisco "a shithole" or whatever hot reactionary word of the day the rest of the country is using to label SF as enemy #1 of traditional american values and are essentially exuberant to have a new single point of data to sling around, and those that are overcorrecting against this and diminishing the real problems in SF in an attempt to whitewash while to be fair making things seem more true to reality, that is to say, portray SF as, statistically speaking, relatively safe and boring for a US metropolitan area.
As a former SF resident I think it's really sad that someone got murdered and I'm really angry about it. I'm mad at whoever did it, what a scumbag. I'm hopeful that there will be justice. I'm also afraid that this might give ammunition to reactionaries that want to overfund or overarm the SFPD, and that this will lend further political strength to politicians like bloodthirsty DAs that get their rocks off to throwing young POC in prison for minor drug offenses.
Cynically, part of me knows that finally some of the issues SF has been facing and the various leaders have been ignoring or handling poorly will probably be handled properly now that a rich person has been murdered. Well, no, cynical me again, probably this just means the cops will be cut loose a bit more and ineffective, punitive policies will be enacted / enforced / tightened.