Very astute! The First! Lab escape happened in 2021. CRISPr was invented in 2000-2005ish. CRISPr cas9 around 2014.

BSL-4 labs have gone from 40 to 60ish in the last 25 years with another coming online almost every year.

BSL-3 labs are virtually uncountable and are in the 13000ish range in the USA alone (sorry, can't Remeber source)

Put it all together, and only an idiot STARTS with natural origin.

Also, there will be many many more.