I miss it too. For me, the replacement is Web. It lacks VB's all-in-one-ness, and it lacks the GUI designer, but other than that, I can get a pretty close approximation of GUI toolkit with events binding.

I don't use almost any frameworks or toolkits, save for a cryptography module, and I am quite happy and getting a similar experience.

Bonus is if I keep it to 2010-ish era DOM-style code, I virtually never have to worry about cross-browser compatibility issues.

It pays to stay off the bleeding edge.

Gambas. Some related links at:

https://github.com/wekan/hx/tree/main/prototypes/ui/gambas

I feel like VB6 was definitely a peak of the integration of beginning and advanced. I wonder if there's anything like it but for HTML, CSS, JS. The style of VB coding is basically frontend webdev today.

Does AutoIt count?

https://github.com/EsportToys/MouseTray

The language is obviously different, but if you miss the "get the GUI done" feature then Lazarus fits the bill.

PureBasic or DarkBasic? Or just use VB6 and a paper bag over your head.

Depends on what you miss. Lazarus might be an alternative?