Recovery of function prototypes in Visual Basic 6 executables
decoded.avast.io
decoded.avast.io
I don't use almost any frameworks or toolkits, save for a cryptography module, and I am quite happy and getting a similar experience.
Bonus is if I keep it to 2010-ish era DOM-style code, I virtually never have to worry about cross-browser compatibility issues.
It pays to stay off the bleeding edge.
At one point you could also embed Python because there was a compatible COM wrapper for it, but it had performance and integration issues and maintenance eventually stopped.