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I recently switched to spideroak, because i didn't want to have another app perform my sync duties seperately. So not only does spideroak back-up my files to the cloud and to my NAS drive, but takes also takes care of syncing all my folders between my computers and laptop (no extra charge for additional devices, unlike other services).

Unlike SpiderOak, CrashPlan lets me backup data between my own machines without charging me for the storage. I wish it would do sync too...

I second the recommendation of Crashplan. Setting it up so my parents can remotely backup to an external drive connected to my machine (to which my own backups of course also go) was a breeze. Ironically, I regularly switch that drive with the offsite backup that I store... at my parents :).

Agreed, Crash Plan have been really good. Their client is fast, useful, and they're really cheap. Plus it can also take local backups, so there's less chance of this situation happening.