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In regards to the difference in effect between Adderall and illegal street meth, Scott thinks the biggest difference is the dosage size, effectively around 50x higher for street meth: https://astralcodexten.substack.com/p/drug-users-use-a-lot-o...

Dosis sola facit venenum.

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And particularly the means--smoking it versus taking orally. A lot of these stims are terrible if snorted or injected, they used to warn patients never to do that or risk becoming addicted.

There is a methamphetamine that is prescribed to ADD's, not the same as the street version of course.

This may not actually be the case: https://www.theatlantic.com/magazine/archive/2021/11/the-new...

I've done a decent amount of drugs, and I've been around people who have done a hell of a lot more, but I recently had a friend develop a meth problem, and I have to say, there is something remarkably different about how issue compared to what I've seen in my life.

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