We'll need to improve our collation and storage of the sum of human knowledge.

Today if you took the scrapable internet + wikipedia + all academic journals, you still probably lack enough detail and method to reproduce techniques in manufacturing, mining, tooling, medicine, and so on.

If the hypothesis is that humans will survive so long as we are off-planet, then the humans leaving the planet need to be able to do everything fully disconnected from the home world to really survive if something happens to the populace on the home world.