For servers, you face the same problem. It's already possible to get power and heat density that is more than what your typical datacenter can handle. If the density increased by even 10 times we would presumably need some serious advances in cooling to be able to handle all those servers.
As I understand you have to make circuits faster and smaller at the same time, so you still have time for clock distribution...
We are talking about pretty radical processor designs. Why not go asynchronous if we are talking about coordinating multiple layers of silicon?
It will be interesting to watch. If real devices built with that technologies start showing in p and zSeries machines before 2015, we'll have some serious performance bump in high-end computers.