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Comment by easymodex | Hacker News Reader

I just got the booster shot today, previous times I had a weird headache and a new vein (felt it pulsing, didn't have it before) popped up in the white part of my eye (it's still there after 6 months), second time I had minor heart palpitations the day after so I'm kinda worried this time. Would taking Aspirin help prevent any kind of weirdness like that? I need to know asap so I can take it before anything potentially starts happening.

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Vaccines are not Covid.

Even the inactivated virus ones. They're just a very small viral load with an adjuvant to enhance immune response.

The mRNA vaccines create spike proteins which are fully functional and will bind to ACE2 receptors. The only real difference is that the mRNA vaccine spike proteins don't cleave off their connectors and litter your blood with extra trash and also won't flex down to the cell wall. But any cell randomly getting a spike protein tag-alone likely will no longer be a fully functioning cell.

Yes! And I think it's fair to assume that the vaccine spike can distribute widely throughout your body. Long covid and a subset of vaccine injury cases are very hard to distinguish. They present the same symptoms.

Why? We can hypothesize anything, but we shouldn’t just assume everything. The manufacturers made changes to the RNA sequence to reduce the ability to leave the cell, and then tested it in animal studies to confirm.

As OP indicates, it can still bind to ACE-2 and that changes the way these cells behave. Peristalsis in your veins is changed when the endothelial cells which have ACE2 are hit with spike (vaccine origin or covid origin) for instance.

I think there's enough evidence out there that spike from vaccines circulate widely. I can dig it up if you want?

You are welcome to look for evidence, but OP is also wrong about the spike protein being "fully functional" in the vaccine. The spike protein sequence was modified in many ways in creating the vaccine, including to prevent it from undergoing the conformal change upon encountering ACE2 which would normally then cause the virus to then enter a cell.

For a sample reference: https://journals.asm.org/doi/10.1128/JVI.00203-21

> But any cell randomly getting a spike protein tag-alone likely will no longer be a fully functioning cell.

Do you actually have any evidence to back this up? Cells have a myriad of receptor sites, and single bindings without other resultant activity are highly unlikely to cause the cell significant damage.

The side effects of the vaccines have nothing to do with the vaccine particles themselves and everything to do with your body's immune response.

Typically speaking the immune system will clear away cells with abnormal stuff on their membranes but I don't know about this specific case.

Unfortunately I think any anti inflammatory is not recommended when you get a vaccine. You want the immune system to be fully armed. That is my recollection from googling when I got my vaccines.

Just hang in there you’ll feel better soon.

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