Antiplatelet and anticoagulant therapy resolves long covid in 24 patients
researchgate.net
researchgate.net
"A proton pump inhibitor (PPI) pantoprazole 40 mg/day was also prescribed for gastric protection. Such a regime must only be followed under strict and qualified medical guidance to obviate any dangers, especially haemorrhagic bleeding, and of the therapy as a whole."
Induced hemophilia is no joke.
Note that this is one of the possible side effect mentionned in Pfizer documentation of their covid vaccine, reported in article research articles like [1], and it doesn't seem to bother too much people.
This HN post talks more about the link: https://news.ycombinator.com/item?id=29808020
Randall Munroe, https://xkcd.com/552/ (mouseover text)
If I eat something and it upsets my stomach, I'm not going to commission a study on it. I'm just gonna avoid eating it.
In the end, when it comes to individual cases of anything (even conditions we have a very strong understanding of), all we can rely upon is guesswork. (e.g. even if we know A causes significantly increased rates of B in study populations based on RCT evidence, it still doesn't tell us for any given person with A & B that their A caused B).
Blood thinners resolved.
When I got covid all the symptoms came back. I had to double my blood thinners for six months.
Actual cause is Factor 5 Leiden. But seems to cause exact same sort of issues.
https://www.nhs.uk/conditions/chronic-fatigue-syndrome-cfs/ > Suggested causes or triggers for ME/CFS include: > viral infections, such as glandular fever > bacterial infections, such as pneumonia > problems with the immune system > a hormone imbalance > your genes – ME/CFS seems to be more common in some families
I have a friend who got CFS out of nowhere (shortly before the 2 years to flatten the curve started, no COVID involved) and it's bad, there is no cure and it's incredibly disruptive. At the same time, it's hard for people to take you seriously and not just call you lazy.
Hopefully this study goes somewhere and we'll find a cure for CFS.
---
from the link cdrini posted above, which is a Guardian article by one of the authors of the study in the original post.[0]
"Even those without long Covid could benefit from such research, as symptoms noted in long Covid patients show many similarities to those seen in chronic and viral-related illnesses including myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) – another disease that has been dismissed as “psychological” for decades. Just because we have not yet identified a biomarker for long Covid does not mean biomarkers do not exist. We just need to look harder."
[0] https://news.ycombinator.com/item?id=29808020
PS. Hope the post is done correctly, it's my first one here.
Further reading:
- https://www.survivingmold.com/Publications/2493-Treatable_me...
- https://www.survivingmold.com/docs/Shoemakers_Protocol_for_p...
- https://www.survivingmold.com/Publications/CIRS_diagnostic_p...
The two most effective approaches are using neuroplasticity exercises to retrain the limbic system (cheap, but time consuming - an hour a day for 6 months): https://ansrewire.com/ https://retrainingthebrain.com/
Or doing microcurrent neurofeedback (costs ~$150 a session, do one session a week for a couple months): https://microcurrentneurofeedback.com/
Essentially you have got to get the brain producing the proper amount and type of brain waves again, and then once you have that, slowly work back into exercising while trying to avoid triggers and push / crash cycles.
I’m triple vaccinated before anyone asks. I haven’t tested positive for Covid on rapid tests but a lot of people seem to be in the boat I’m in right now.
In the UK there is a large, ongoing clinical trial called 'RECOVER' to test different COVID treaments for hospitalised COVID patients. One of the trials included giving hospitalised patients aspirin. The trial was not looking at the treatment of long-covid symptoms (at least not directly in hospital patients).
"A total of 7351 patients were randomised to aspirin 150 mg once daily and compared with 7541 patients randomised to usual care alone. There was no evidence that aspirin treatment reduced mortality."
Link: RECOVERY trial finds aspirin does not improve survival for patients hospitalised with COVID-19: https://www.recoverytrial.net/news/recovery-trial-finds-aspi...
And, I'm aware of the research (and money) being poured into antivirals. Of course that's a thing. I'm sure there are billions if not trillions to be made off a pill you "simply take daily" to prevent the "severe and long covid." The headlines write themselves. But I seriously wonder what research is being done on "mild" covid cases using more cheap/traditional medicines. I know where I live, the doctors don't even talk to you unless your case gets severe - basically once you need oxygen supplementation. Prior to that, you're told to stay home and rest. I'm not even sure they create a record in their medical system.
This seems to be a problem with every account of "treatment X doesn't work". They wait until someone is half dead, use X, patient dies at same rate as without X, conclude X is worthless. "preventive" or "protective" are different words than "curative" and that seems to get overlooked in a lot of cases.
Doctor A: When I see someone with Covid Symptoms I give XYZ and they never end up in the hospital.
ER Doctor: We've tried X,Y, and Z in every combination with patients on ventilators and none of that saves them with any statistical significance.
They can both be correct.
Take for example the very recent approval of Molnupiravir:
https://www.bbc.co.uk/news/health-59163899
https://www.nejm.org/doi/full/10.1056/NEJMoa2116044
We conducted a phase 3, double-blind, randomized, placebo-controlled trial to evaluate the efficacy and safety of treatment with molnupiravir started within 5 days after the onset of signs or symptoms in nonhospitalized, unvaccinated adults with mild-to-moderate, laboratory-confirmed Covid-19 and at least one risk factor for severe Covid-19 illness.
Also, adverse-drug interactions is potentially a a major killer already in the US, sometimes from doctors making mistakes, and often from people using OTC drugs outside of their safe regime.
So then, we might wait until it is clear that intervention is necessary, but now the intervention also probably needs to be much more aggressive.
And besides, we do have a pretty good preventative/protective option already in vaccines. It is only when breakthrough cases lead to hospitalization that we then need to pull out the backup strategies, otherwise, we’ve seen that statistically our primed immune systems are usually pretty good at dealing with it on their own.
I’m not worried about mortality so much as getting over the strange long effects I’m feeling. I see this study as well.
https://www.webmd.com/lung/news/20210315/low-dose-aspirin-ma...
> But Magen's group found that people who'd already been taking low-dose aspirin to reduce their risk of heart disease had a 29% lower risk of contracting COVID-19 compared to those who didn't take aspirin, and that rates of aspirin use were much lower among COVID-19 patients than among those who didn't get infected.
>Among people who did get COVID-19, the time it took for SARS-CoV-2 PCR test results to go from positive to negative was significantly shorter among those who used aspirin, and the duration of their disease was two-three days shorter, depending upon preexisting health conditions.
How is survival defined? Do they mean "gets released from hospital vs. dies in hospital"? Because it seems a lot of things that can reduce severity of Covid (including vitamin D for example) don't change much at the last minute when you're at deaths door.
In this case, we're talking about long Covid symptoms so it would seem a reduction in 1-year mortality should be the deciding factor (since Severe Covid patients who "survive" still have significantly increase mortality over the next year).
Hmm, this is probably hardcore anecdata and off topic but a friend of mine who got Corona pretty bad (but not hospital bad) said that once he took Aspirin his symptoms weren't that bad anymore.
"Such a regime must only be followed under strict and qualified medical guidance to obviate any dangers, especially haemorrhagic bleeding, and of the therapy as a whole."
Also placebo are getting stronger https://drdavidhamilton.com/the-placebo-effect-is-getting-st... ;)
https://www.nytimes.com/2021/10/12/health/aspirin-heart-atta...
Even the inactivated virus ones. They're just a very small viral load with an adjuvant to enhance immune response.
I think there's enough evidence out there that spike from vaccines circulate widely. I can dig it up if you want?
For a sample reference: https://journals.asm.org/doi/10.1128/JVI.00203-21
Do you actually have any evidence to back this up? Cells have a myriad of receptor sites, and single bindings without other resultant activity are highly unlikely to cause the cell significant damage.
The side effects of the vaccines have nothing to do with the vaccine particles themselves and everything to do with your body's immune response.
Just hang in there you’ll feel better soon.
If aspirin did anything for covid you'd be seeing it on the news every single day for the past two years.
And yet there’s hardly any mention of them, let alone “everyday”.
https://www.covid19treatmentguidelines.nih.gov/tables/fluvox...
"No difference between arms in time to symptom resolution"
"Fluvoxamine did not impact time to symptom resolution"But I also found for remdesivir, which in the US and Israel is given like candy. My point being “hear about it everyday” is more related to politics and agenda than actual efficiency.
I couldn’t handle side effects, so I switched to Aspirin. It mostly works. But not as well. Side effects aren’t as bad. Doctors are pissed. But quality of life matters.
I would absolutely NOT do the same with ibuprofen or any other NSAID. All other NSAIDs but aspirin have been shown to reduce blood vessel elasticity after habitual use. Adopting any med for regular use is not something to take lightly.
"Ibuprofen, aspirin, and COX-2s all belong to the class of medicines called nonsteroidal anti-inflammatory drugs (NSAIDs). Most of them boost blood pressure and can counteract the effect of some blood-pressure drugs. They can also impair blood vessels' ability to relax and may stimulate the growth of smooth muscle cells inside arteries. All these changes can contribute to the artery-clogging process known as atherosclerosis."
https://www.health.harvard.edu/press_releases/nsaid-side-eff...
As a related question, how is Japan doing in terms of long covid cases relative to everywhere else? They eat a lot of Natto.
The article topic covers fibrin amyloid microclots which is precisely what many surgeons have used these enzymes for in addition to removing scar tissue from the vasculature. On a side note this is a very divided and heated topic within the different groups of heart surgeons.
Would be interested in hearing what your approach here is, or any literature you could share.
Correct.
Here [1] is one of the studies though there are quite a few on nih.gov that vary in results and P-value. In full disclosure I use much higher FU's than what is used in their test and have been using it for a long time building up to those levels so my risks are lower. I use this in combination with vascular de-calcification methods and other molecules that break down plaques.
I don't have any of them handy but you can also find some videos that talk about the different mechanisms that Natto interact with that affect BP. It is surprisingly not what one might expect. While it does bind to ACE2 that has a very insignificant role in BP. The biggest effect comes from how it changes a feedback mechanism in a peptide chain. I was taken aback when I learned how many roles peptides play in mammals well beyond tissue repair.
On a fun side note Natto also has an effect on von Willebrand factor which is also plays a significant role in covid.
I should of course add that I am not a doctor and this is not medical advise. Enzymes can break down scar tissue, plaques and more. These come with some risk of bleeding and stroke - one must study the risks and discuss with their doctors that will likely give them blank stares until they say "orally bioavailable tissue plasminogen activator" which is not entirely correct but it will help them understand the intent and might tickle their curiosity.
I am an expert in the field of clotting mechanics (US NIH funded research / vascular surgery fellow). Not sure why they chose TEG to monitor coagulation status - it does not reflect well changes from any of the drugs used in the study.
It would be interesting to see the results broken down by gender - females respond much differently to aspirin and have less of a survival benefit than males (don’t get me started, many of the initial trials in the 60’s with aspirin were done with mostly males).
Also, in my own research - we have found that aspirin “softens” clots which allows platelets to squeeze pathological clots to smaller sizes, which allows more recannalization of thrombosed vessels and thus less ischemia - would be interesting to see if that same MOA happens here.
Do you recommend aspirin to thin blood for flights where I am sitting with legs bent and pressure from the seat underneath the leg pressing into the skin contributing to clotting?
The trick is balancing risk vs. benefits. Anticoagulants and antiplatelet will kill a 30 yo healthy person who slips on ice and hit his head. Your mild concussions are now massive brain bleeds.
Sorry, what? You’re telling us that you were treating long COVID patients in the ICU when the pandemic started?
I don’t know if you misspoke or misread the headline or what, but in no way is it possibly true that you were treating long COVID with anything in the ICU at the beginning of the pandemic, or any time for that matter.
2. None of this matters to the claim I addressed. Long COVID it’s not something that would be treated in an ICU. It’s also not something that even had a name “when COVID hit”.
(1) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378457/
Attached article was written during initial outbreak
You knew the solution to long COVID and just kept it quiet? The NIH was publishing guidance to give anticoagulants to hospitalized acute COVID patients but just neglected to tell people the cure to long COVID?
I’ve got no dispute that you knew to give hospitalized patients anticoagulants early on. My statement is that this is a different thing than knowing to treat long COVID with a related protocol. This study hasn’t even been published yet, has it? This is a preprint we’re discussing. Have there been a bunch of other studies showing this is a viable treatment I’m unaware of (this is certainly possible)? Or is this new data?
This study is not establishing a new treatment protocol by any means. It’s also a tiny number of people.
This study raises the question maybe we should design bigger trials to investigate treating long COVID with blood thinners.
So this was a known treatment protocol? That’s interesting. I hadn’t heard much about long COVID that wasn’t “we have no real idea”.
I also find this a really odd line to draw. The fact that treating ICU patients with anticoagulants is standard does not automatically mean it’s useful for long COVID patients. If it turns out that it’s useful, awesome, but it’s not obvious a priori.
Pretty cool that they're ahead of the curve on this.
Even if they didn't know about long covid officially, they followed the known science up to that point, and this is incompletely but interesting new data that's showing it's helping more than possibly known at the time.
If someone published a study that CTE resolves with a month of Tylenol supplementation, this would be huge news. The fact that acute concussion pain is treated with Tylenol in no way implies this result.
In that sense they were ahead of the curve because its looking like it is helpful with long covid as well, which is great news!
It's resolving a symptom, not the cause and there's no long-term followup to see if the results stuck around.
I'm no expert, but intuitively this would seem to provide a good explanation of those symptoms.
I suddenly got similar symptoms since getting a nasty version of strep throat last October. Notably I had an elevated fever (>102F) for quite a few days straight. I've never had COVID but I did get the mRNA vaccines + booster.
Since that fever, my heart goes into light arrhythmia all too frequently. It used to be maybe once or twice a year I'd notice 1-3 seconds of "off-beat" heart pattern. All of of a sudden it's a few times a week. I'm also getting older (entering mid 30's now), live in some of the worst air quality in the US (next to a bunch of chemical plants which are frequently releasing quantities of ethylene oxide/mercaptans/styrenes/acrylates/etc), and haven't been exercising much at all the past few years (largely due to air quality issues). My diet isn't the best either, but I incorporate a lot of fresh salmon which keeps my blood pressure down, triglycerides low, and HDL really quite high.
There's probably more I could do to help myself using just current medical knowledge, but additional knowledge and medical practices are always, always welcome IMO.
Out of curiosity, where do you live? I too live next to a bunch of chemical/steel plants and have been tracking air quality, weather, traffic, etc. https://millerbeach.community in Gary for a few years. Winds from North>South produce the best air quality, E>W or W>E produce worse, same with S>N.
It's based on somewhat-voluntarily reported data, rather than measured air samples. Mainly because we don't have effective air monitoring stations in anywhere near enough density to any kind of useful data science.
[0] https://theethicalskeptic.com/2021/11/15/chinas-ccp-conceale...
Or do you rely solely on appeals to authority when filtering signal from noise? I’ve noticed throughout this pandemic that many arguments supported on such a weak basis have later been disproven or severely undercut by further evidence.
Some examples: the virus likely leaked from a lab (at some time); masks reduce transmission; the virus is airborne; there is no sterilizing vaccine; vaccinated people can catch and transmit Covid; vaccines have waning efficacy; “fully vaccinated” will eventually turn to “recently vaccinated;” the mRNA vaccines can lead to myocarditis to such a degree that their risk may not outweigh their benefit for some age groups; a variant will eventually emerge with a high degree of immune escape…
There are many examples of conspiracy theories becoming mainstream narrative months later. So while many of them remain conspiracy theories, and the information environment continues to be overwhelmingly noisy, it seems imprudent to discount a source based on appeal to an authority that has been so consistently wrong, sometimes even willfully so (like when CDC lied that “masks don’t work” in order to save them for healthcare workers).
It's a workday and I'm busy but I'll grant you one substantive critique; the OP heavily relies on "mutations per year" as a metric to derive how plausible it is that something like Omicron could have mutated in the timeframe necessary.
Does it strike you as a bit suspect to rely on a mutations/time period, and completely ignore the number of infections? It should. The rate of mutations/year is a useful metric for determining the average mutation rate between two different viruses given certainty of their dates -- it's not at all useful for "aging" a specific variant because the calculation is independent of the number of infections.
We're in the midst of a pandemic with hundreds of millions of infections, so the selection pressure for more "fit" viruses is immense. OP tries to get around this by claiming that the rate of mutation that we've actually measured (which is an order of magnitude higher than his assumption!) is suspect and would "extinguish SARS COV2 within a season" but that's just gibberish.
I don’t like words like “believe” that imply a reliance on faith. I seek truth through evidence and my goal is to filter signal from noise.
> Does it strike you as a bit suspect to rely on a mutations/time period, and completely ignore the number of infections?
I’m far from a virologist, but I think OP’s postulation around mutation frequency is a bit more subtle than simply N / time.
See Exhibit [7.7] for example, which makes it visually clear just how distinct omicron is from any other variant. I’m not qualified to speculate beyond this, but it seems OP is saying a bit more than “there are a lot of mutations” – indeed, he spends multiple sections disambiguating the evidence of pure volume of mutations from that of phylogenetic distance. Still, you may have a point — maybe it only takes one mutation into a new dominant “clade” to produce such distinction, with any subsequent mutation being of little surprise given the prevalence established by the first one.
> It's a workday and I'm busy
On this we can agree.
[7.7] https://i0.wp.com/theethicalskeptic.com/wp-content/uploads/2...
I, and nearly every colleague in the downtown San Francisco office I worked at, contracted Covid in early January 2020. There should be no doubt that there was already widespread community transmission in California in late 2019. Yet, strangely, "hospital capacity" did not become a concern until right after the U.S. declared a nationwide state of emergency in March.
Why was it not a problem in the nearly 4 months prior? I believe many people were convinced that the virus was far more dangerous than it was, and voluntarily began seeking hospitalization when none was actually needed.
You need to exercise. You are in your mid-thirties now. It's a big problem if you don't. But you have bad air quality where you live. I've dealt with this myself in the past.
A relatively inexpensive solution that I recommend for anyone in areas with poor air quality is to build your own filter fans. Get a standard box fan, get a furnace filter that has HEPA ratings, duct tape the furnace filter to the back of the fan. One of these in a whole house does a good job. Put three of them in there and it's crazy how big of a difference it makes. My wife has respiratory issues and my son has asthma. My wife had to be hospitalized twice for wildfire smoke in my neighborhood. Once I started doing the filter fan trick the issues went away. You can then work out in your home. Used cardio equipment is ridiculously easy to come by. I purchased a reflex punching bag for my basement a few months ago and it's the best piece of cardio equipment I've ever gotten. Doesn't take up too much space wasn't too expensive either.
I applaud you on your diet though. You definitely have a good grasp of the metrics that matter. Low triglycerides and high HDL are crucial, and good for you keeping that blood pressure solid. That diet is clearly doing good things for you.
Just keep in mind that exercise does great things for mental health by relieving stress via hormones.
One side note:
You may have contracted covid and never known it. The only reason I knew I caught it back in February of 2021 was because of my complete loss of sense of smell. If not for that single symptom I would have never known I had it. It didn't impact me in any other way. My wife and kids caught it as well and had absolutely no symptoms. They only knew they caught it because they got tested along with me.
Please be very careful with this. This significantly strains the motor of your average cheap box fan, and hot motors tend to die faster and can get hot enough to melt plastic and start fires.
I'd really recommend an actual air purifier instead, especially if it will run while you're asleep or not at home.
Your advice for air filters is good general advice, IMO. I have a 700 sqft apartment with:
1x Honeywell HPA300 (rated for 465 sqft)
6x Coway AP-1512HH (each rated for 361 sqft)
1x Honeywell HPA100 (rated for 155 sqft)
I also have a Honeywell FPR 10 filter on the HVAC air return. So, over 2800 sqft of CADR-rated filtering for a 700 sqft apartment. Activated carbon pre-filters are changed every 2 weeks and the HEPA filter is changed once a month. We spend about $400/mo on filters, on top of $1,100/month rent.
Unfortunately, HEPA filtration does little for the type of air contamination that we're dealing with. Ethylene oxide is more like a "VOC" than a "PM2.5". The activated carbon filters help a bit, but are "used up" very quickly (1-2 days IME). The HEPA filters do very little/nothing for VOC contamination as far as we can tell.
Indeed, it is time to move away. I am in one of the most heavily-affected featured areas in this article[0]. However, my wife and I work in the chemicals industry, so we have personal experience identifying most of the compounds by smell and have unusual awareness of their effects vs. most of the nearby citizens.
0: https://www.propublica.org/article/toxmap-poison-in-the-air
Really terrible to hear this. You aren't fucking around with this, but it's still not enough. $400 a month on filters is insane.
Thanks for that article. Very eye-opening.
I hope you get out of there soon, but I can't imagine the guilt you feel for the citizens left behind. Horrible.
Basically, you're making a cube. One side is the box fan, with the intake coming from the inside of the cube. The other sides are taped together filters. It significantly reduces the strain on the motor of the fan, and you can use the cube for a long time before replacing the filters, since each one is filtering so much less air.
> my heart goes into light arrhythmia all too frequently. It used to be maybe once or twice a year I'd notice 1-3 seconds of "off-beat" heart pattern. All of of a sudden it's a few times a week. I'm also getting older (entering mid 30's now)
This is my situation exactly, starting a few weeks after getting my second booster (Moderna). I've read enough anecdotes and news reports to believe there are many people dealing with this:
https://www.cbc.ca/news/canada/ottawa/myocarditis-ottawa-mrn...
https://ottawacitizen.com/news/local-news/she-thought-she-wa...
It gradually improved (enough to stop waking me up), but I still get a lot more "off-beats" than I used to. Got my third booster recently (Pfizer), so far no major regressions.
Out of curiosity, if you noticed these negative side-effects affecting the health of your heart after the second shot, why did you choose to proceed to get a third shot?
Lesson learned in honestly answering “are you fully vaccinated”. I still get told I should do it 8 months later.
I had similar symptoms to what you describe after just not being very active for quite a while, but it resolved after I did regular cardio (cycling) for a while and ate better.
> I've never had COVID.I did get the mRNA vaccines + booster.
Regardless of root cause, probably just need to exercise more. See a doctor for good measure. Could be age/underlying condition, but exercise improves most of these things.
It slowly resolved itself after some 4-6 months, but not on its own, I needed small dosage of Concor prescribed by the cardiologist.
So while they prevent ischemic stroke and help with circulation, they might cause hemorrhagic stroke. The dose and time duration has to be carefully adjusted. It’s a slippery slope in dealing with cerebrovascular accidents.
Anti platelets (specially Aspirin 80 and Clopidogrel) are less risky than anticoagulants (such as heparin or warfarin).
https://pubmed.ncbi.nlm.nih.gov/3063394/
But many cases of "long covid" appear to be psychosomatic.
https://jamanetwork.com/journals/jamainternalmedicine/fullar...
And then, just as you say, there's "long covid", which is a large number of people who have very generic ailments, and if you start digging into the numbers, you realize it's all self-reported bullshit, where a good chunk of the sufferers haven't even been diagnosed with covid in the first place! Their symptoms match depression very well, though.
It's extremely frustrating watching people like my friend getting ridiculed for having an imaginary disease. She doesn't. And at the same time it's even more frustrating watching a relatively huge number of psychosomatic hypochondriacs getting all the attention and using up the wrong kind of healthcare resources, just because a lot of people are using long covid for generating fear porn and want it to be worse than it is.
https://www.washingtonpost.com/politics/biden-ada-long-covid...
Medically it just seems to fall outside the flowcharts of modern medicine where an "easy fix" or "procedure" is not prescribed. Going outside of the "acceptable medicine" of what insurance will cover is practically a unicorn event. So you'll see a lot of doctors just calling it "anxiety." Functionally, Long Haul Covid has become a huge cash bonus to medicine as sufferers get referred (passed around) from specialist to specialist for more testing and diagnostics that nearly always comes up as "normal."
About the only good news about this situation is very likely once they really get the studies done (and they're going to have to do it, because there will be millions of people suffering from this) they are likely also going to find how to help people with chronic fatigue syndrome (CFS) since all the long hauling symptoms appear to over lap. CFS sufferers already have had the feeling of being ignored/ridiculed by medicine for decades.
Highlighted on the page: "As of July 2021, 'long COVID,' also known as post-COVID conditions, can be considered a disability under the Americans with Disabilities Act (ADA). "
https://covid19criticalcare.com/covid-19-protocols/i-recover...
For instance, see Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus.
Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug.
A screen of FDA-approved drugs for inhibitors of Zika virus infection.
If someone is catastrophically and unapologetically wrong on problem 1a, you don't really need to pay attention to their solution to problem 1b.
Just published now:
https://www.motherjones.com/politics/2022/01/desperate-patie...
These people should be in prison.
And if I understand your timeline right --- you think a single dose of the vaccine gave you "long covid" symptoms? So you're going to rely on the long-covid treatment path, even though you've never had the virus? Yikes man..
My story: got all the long covid symptoms, started eight hours after the AZ vaccine. Tested negative twice on pcr. 3.5 months with little improvement. Optometrist noted blood heme in eye, had a clot removed from forehead vein recently. Both of those noted within a week or three of vaccine date. At the 3.5 month date I started that protocol, first with ivermectin. Within five hours I felt better than I had in the past three months and then in five days brain fog, sob, headaches, extreme fatigue, heart issues, high blood pressure all resolved. I quit the daily dose of ivm then and started prednisone for remaining lung inflammation. (Describe this like extreme asthma, any deep inhalation would trigger coughing). That worked. I still have a bit of a dry like congestion that lingers (8 months since vax).
Maybe I caught covid same time frame as vax but the two negative tests seem to not support that. The symptoms certainly presented right after the shot. They very clearly resolved a few hours after the ivermectin. It was like a light switch. My wife noticed improvement in my color even.
Also, why did it take over a year to publish when the study ran from July-Dec 2020?
Started reading it now, and what? Why can't these people do real science?
> "Although study design, IRB approval, and data analysis occurred after completion of the voluntary prophylaxis program, all data were collected prospectively in real-time with mandated reporting to the registry of all events as they occurred during the citywide governmental COVID-19 prevention with ivermectin program"
https://www.nydailynews.com/coronavirus/ny-brazilian-mayor-t...
And what now -- the 2nd author is facing prison for massive ethics violations running a different covid study?
https://sei.saude.gov.br/sei/controlador_externo.php?acao=do...
The advocates for IVM are consistently some of the worst acting scientists on the planet. It's a real disservice to their stated goal that they're all so incompetent.
There's no benefit to cosplaying as Socrates when there is no data point or research result that could change the mind of these weird conspiracy theorists. If a well-done study came out tomorrow that demonstrated Ivermectin worked to help Covid patients, it would literally be in every hospital's protocol tomorrow.
On the opposite side, these charlatans have been promoting IVM since March 2020 with absolutely no evidence of efficacy (often at the expense of convincing people to not get vaccinated). What little evidence has come out has only weakened the case for it as a treatment, and yet, they're still promoting it as fervently as ever.
If you want a long-covid treatment protocol, you should absolutely look somewhere else aside from the pages of the most stubbornly wrong people in this whole pandemic. They've shown repeatedly that they don't care about updating their priors when there's contradictory evidence. At least the HCQ dorks have mostly retired to complaining about cancel culture.
Before personally taking the medicine we spent 1.5 weeks reading everything we could find. Straight from Google Scholar or pubmed. Respectfully, I disagree with you. But that's based on my own reading and I'm not an MD or medical professional.
I would say, a) it is very common in certain countries, and like hey, they awarded the Nobel Prize in Medicine partially for it in 2015, but b) we have to agree to disagree here, were just too far apart on tone. But respect your point of view.
We have hundreds of millions of active infections, it's dead-simple to do research studies to determine whether something prevents hospitalization, or shortens length-of-stay, etc etc. You don't have to spend weeks of your life reading primary materials -- here's the EUA for Paxlovid (Section 14):
https://www.fda.gov/media/155050/download
A pre-registered RCT, with specific endpoints and statistically significant evidence that it lowers viral load, and prevents hospitalization and death. It only took 4 months from study enrollment -> results to see how effective it was. Paxlovid works! Hurray! IVM doesn't. Rats.
Good faith individuals would move on and investigate something else that could help humanity but admitting you were wrong doesn't get you invited onto Joe Rogan so here we are, with people still referencing their nonsense.
Ketamine is widely available and cheap, but the FDA approved esketamine (the S enantiomer of ketamine) and gave the pharma companies a patent for the formulation so they would fund the clinical trials that are needed for it to be used as a treatment of depression.
Esketamine is much, much more expensive than ketamine, and essentially the same molecule, yet it hasn't been 'outcompeted' by ketamine (in the context of treating depression).
Because the new ivermectin (newermectin) would be specifically authorised and used to treat covid, it would have a niche advantage over ivermectin. Ivermectin would still dominate treating parasites, but there would still be good money in developing newermectin.
Maybe it's a disease + chronic unhealth. Due to age, pollution, obesity, bad diet, sitting on yr butt too much and/or etc
And there are a thousand species of varmint that inhabit our body without helping or hurting anyway.
So yes, massive unhealth can definitely spell the difference there.
A disease requires some minimum proportion of the infected to feel it. Otherwise it's just commensalism or something.
Therefore, as the general health shifts, so does what we call our relationship with that varmint.