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Comment by treeman79 | Hacker News Reader

Nightshades are also inflammatory for some autoimmune conditions.

Supposedly because they contain glycoalkaloids. I'm not sure who invented the Autoimmune Protocol (AIP), but it seems to have the same scientifically questionable origins as Leaky Gut Syndrome. I have yet to see any scientific evidence supporting AIP.

There's one study hypothesizing that glycoalkaloids can increase/aggravate intestinal permeability (which is a real thing), but this study only looked at mice [1]. The hypothesis has not been rigorously tested in any serious clinical study on humans.

[1] https://pubmed.ncbi.nlm.nih.gov/12479649/

> I have yet to see any scientific evidence supporting AIP.

The food elimination diet is very scientific - you add items back in one at a time to test if they cause a negative reaction to your particular physiology.

That’s what I ended up doing. Ate nothing but sweet potatoes for a month. It was the only food I was sure didn’t cause a problem.

Most boring month ever. Felt amazing at the end of it.

Was shocking when I introduced things back in.

I've just finished a five day water fast and plan to limit my diet, introducing new types of food slowly while observing any undesirable effects. Would you mind sharing some of the foods which you found most surprising or troublesome?

Basically what is safe on AIP worked for me. Everything else is bad.

Chocolate and “diet” drinks turned out to be massive migraine triggers for me. That was a big surprise

Elimination diet, sure. I meant evidence that the specific foods listed in AIP are inflammatory. I'm not contesting that it works.

Here is one study on AIP

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5647120/

It’s also been life changing for me and many others with Sjogrens.

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